Activity

CI 4.2-7.5) n = 1,918, with baseline prevalence rate of 6.1% (95% CI 3.9-9.4), n = 481 and 3

follow-up survey prevalence of 3.6% (95% CI 2.0-6.8) n = 494. At all the three parasitological follow-up survey points, house screening significantly reduced the malaria prevalence by 100% (p < 0.001), 63.6% (p = 0.026), and 100% (p < 0.001) in the 1st, 2nd and 3rd follow-up surveys respectively.

The study demonstrated that house eave screening has potential to reduce indoor vector densities and malaria prevalence in high transmission areas.

The study demonstrated that house eave screening has potential to reduce indoor vector densities and malaria prevalence in high transmission areas.

To assess the associations between aspartate transaminase/alanine transaminase ratio (DRR) and mortality in patients with polymyositis/dermatomyositis-associated interstitial lung disease (PM/DM-ILD).

This was a retrospective cohort study, which included 522 patients with PM/DM-ILD whose DRR on admission were tested at West China Hospital of Sichuan University during the period from January 1, 2008, to December 31, 2018. Cox regression models were used to estimate hazard ratios for mortality in four predefined DRR strata (≤ 0.91, 0.91-1.26, 1.26-1.73, and > 1.73), after adjusting for age, sex, DRR stratum, diagnosis, overlap syndrome, hemoglobin, platelet count, white blood cell count, the percentage of neutrophils, neutrophil/lymphocyte ratio, albumin, creatine kinase, uric acid/creatinine ratio, triglycerides, or low-density lipoprotein.

Higher DRR (> 1.73) was an independent predictor of 1-year mortality in multivariate Cox regression analysis (hazard ratio 3.423, 95% CI 1.481-7.911, p = .004). Patients with higher DRR more often required the use of mechanical ventilation and readmission for acute exacerbation of PM/DM-ILD at 1-year follow-up.

Higher DRR on admission for PM/DM-ILD patients are associated with increased mortality, risk of mechanical ventilation, and hospitalization in 1-year follow-up. This low-cost, easy-to-obtain, rapidly measured biomarker may be useful in the identification of high-risk PM/DM-ILD patients that could benefit from intensive management.

Higher DRR on admission for PM/DM-ILD patients are associated with increased mortality, risk of mechanical ventilation, and hospitalization in 1-year follow-up. This low-cost, easy-to-obtain, rapidly measured biomarker may be useful in the identification of high-risk PM/DM-ILD patients that could benefit from intensive management.

Accurate forecasting of medical service demand is beneficial for the reasonable healthcare resource planning and allocation. selleck inhibitor The daily outpatient volume is characterized by randomness, periodicity and trend, and the time series methods, like ARIMA are often used for short-term outpatient visits forecasting. Therefore, to further enlarge the prediction horizon and improve the prediction accuracy, a hybrid prediction model integrating ARIMA and self-adaptive filtering method is proposed.

The ARIMA model is first used to identify the features like cyclicity and trend of the time series data and to estimate the model parameters. The parameters are then adjusted by the steepest descent algorithm in the adaptive filtering method to reduce the prediction error. The hybrid model is validated and compared with traditional ARIMA by several test sets from the Time Series Data Library (TSDL), a weekly emergency department (ED) visit case from literature study, and the real cases of prenatal examinations and B-ultrasounds in a maternal and child health care center (MCHCC) in Ningbo.

For TSDL cases the prediction accuracy of the hybrid prediction is improved by 80-99% compared with the ARIMA model. For the weekly ED visit case, the forecasting results of the hybrid model are better than those of both traditional ARIMA and ANN model, and similar to the ANN combined data decomposition model mentioned in the literature. For the actual data of MCHCC in Ningbo, the MAPE predicted by the ARIMA model in the two departments was 18.53 and 27.69%, respectively, and the hybrid models were 2.79 and 1.25%, respectively.

The hybrid prediction model outperforms the traditional ARIMA model in both accurate predicting result with smaller average relative error and the applicability for short-term and medium-term prediction.

The hybrid prediction model outperforms the traditional ARIMA model in both accurate predicting result with smaller average relative error and the applicability for short-term and medium-term prediction.

We here report on the first observation of a C3 mutation that is related to atypical hemolytic and uremic syndrome (aHUS), which occurred in a pancreatic islet transplant patient. Immunosuppressive treatments, such as calcineurin inhibitors, have been linked to undesirable effects like nephrotoxicity.

A 40-year-old man with brittle diabetes, who was included in the TRIMECO trial, became insulin-independent 2 months after pancreatic islet transplantation. About 15 months after islet transplantation, the patient exhibited acute kidney injury due to aHUS. Despite plasma exchange and eculizumab treatment, the patient developed end-stage renal disease. A genetic workup identified a missense variant (p.R592Q) in the C3 gene. In vitro, this C3 variant had defective Factor I proteolytic activity with membrane proteins as cofactor proteins, which was thus classified as pathogenic. About 1 year after the aHUS episode, kidney transplantation was carried out under the protection of the specific anti-C5 monoclonal antibody eculizumab. The patient had normal kidney function, with preserved pancreatic islet function 4 years later.

Pancreatic islet transplantation could have triggered this aHUS episode, but this link needs to be clarified. Although prophylactic eculizumab maintains kidney allograft function, its efficacy still needs to be studied in larger populations.

Pancreatic islet transplantation could have triggered this aHUS episode, but this link needs to be clarified. Although prophylactic eculizumab maintains kidney allograft function, its efficacy still needs to be studied in larger populations.