Bolton Mikkelsen

emic effect in the experimental rats and increased the volumes of the pancreatic islet cells as well as ameliorated the pathological changes in the pancreas.Blighia unijugata (Sapindaceae) is an indigenous tree belonging to the tropical forests of West Africa. It is called “Ako Isin” by the Yoruba people of Southern-Western part of Nigeria, where…[Read more]

A striatal volume is populated with reconstructed neuronal morphologies with appropriate cell densities, and then we connect neurons together based on appositions between neurites as possible synapses and constrain them further with available connectivity data. Moreover, we simulate a subset of the striatum involving 10,000 neurons, with input…[Read more]

Assessment of cytotoxicity showed that etoposide nanoparticles with PGA85%C18 were more potent than an equivalent amount of free drug. This screening method to match polymers to drugs to monitor based drug and polymer interactions thus resulted in the formulation of nanoparticles with higher drug loading and slower release and potential for…[Read more]

The release of oil and gas at Mississippi Canyon Block 20 into the Gulf of Mexico has vexed response officials since 2004 when a regional seafloor failure toppled the Taylor Energy Company platform. Despite the completion of nine intervention wells, releases continue from the seafloor, mostly captured by a recently installed containment system.…[Read more]

This positive relationship between biodiversity, sCOD removal and biomass gross yield was also observed when considering metabolic profiling (functional diversity) or evolutionary relationships (phylogenetic diversity). The positive effect of biodiversity on sCOD removal efficiency could be attributed to the selection of a particular,…[Read more]

Recent studies have found that microRNA-29a (miR-29a) levels are significantly lower in fibrotic livers, as shown with human liver cirrhosis. Such downregulation influences the activation of hepatic stellate cells (HSC). Phosphoinositide 3-kinase p85 alpha (PI3KP85α) is implicated in the regulation of proteostasis mitochondrial integrity and…[Read more]

However, upon carcinogenesis, TNTs proliferate and provide an alternative route of communication to enable the transfer of several signaling molecules and organelles to spread disease and toxicity. We propose that TNTs and their cargo are an attractive therapeutic target to reduce or prevent cancer development. All these unique aspects of…[Read more]