Activity

Two often-studied forms of uncertain decision-making (DM) are risky-DM (outcome probabilities known) and ambiguous-DM (outcome probabilities unknown). While DM in general is associated with activation of several brain regions, previous neuroimaging efforts suggest a dissociation between activity linked with risky and ambiguous choices. However, the common and distinct neurobiological correlates associated with risky- and ambiguous-DM, as well as their specificity when compared to perceptual-DM (as a ‘control condition’), remains to be clarified. We conducted multiple meta-analyses on neuroimaging results from 151 studies to characterize common and domain-specific brain activity during risky-, ambiguous-, and perceptual-DM. When considering all DM tasks, convergent activity was observed in brain regions considered to be consituents of the canonical salience, valuation, and executive control networks. When considering subgroups of studies, risky-DM (vs. perceptual-DM) was linked with convergent activity in the striatum and anterior cingulate cortex (ACC), regions associated with reward-related processes (determined by objective functional decoding). When considering ambiguous-DM (vs. JTC-801 Opioid Receptor antagonist perceptual-DM), activity convergence was observed in the lateral prefrontal cortex and insula, regions implicated in affectively-neutral mental processes (e.g., cognitive control and behavioral responding; determined by functional decoding). An exploratory meta-analysis comparing brain activity between substance users and non-users during risky-DM identified reduced convergent activity among users in the striatum, cingulate, and thalamus. Taken together, these findings suggest a dissociation of brain regions linked with risky- and ambiguous-DM reflecting possible differential functionality and highlight brain alterations potentially contributing to poor decision-making in the context of substance use disorders. BACKGROUND We evaluated the prevalence of sexualized drug use (Chemsex) and its association with moderate/high risk for substance use disorders and HIV sexual risk behavior among men who have sex with men (MSM). METHODS We conducted a cross-sectional web-based survey among MSM from Rio de Janeiro (Brazil). The Alcohol, Smoking and Substance Involvement Screening Test (ASSIST) was used to screen people at moderate/high-risk for substance use disorders. Individuals found to be using substances in the prior three months were asked if they used before/during sex. Sexualized drug use was classified into no sexualized drug use, sex using only alcohol (alcohol-sex), sex using only illicit drugs (drug-sex) and sex using alcohol and illicit drugs (alcohol-drug-sex). The questionnaire included questions about sociodemographic, HIV status/prevention and risk behavior. A multinomial regression model was performed to assess the factors associated with sexualized drug use. RESULTS Overall, 1048 MSM completed the questionnaire; median age was 29 years. Prevalence of alcohol and illicit drug use in previous 3 months was 89 % and 49 %, respectively. Most MSM (64 %) reported sexualized drug use 28 % alcohol-sex, 9 % drug-sex and 27 % alcohol-drug-sex. Median ASSIST scores were higher among those reporting sexualized drug use compared to no use. All HIV sexual risk behavior variables presented increasing prevalence across the outcome categories. In the adjusted multivariate model, having moderate/high-risk for substance use disorders were associated with sexualized drug use. CONCLUSIONS MSM reporting sexualized drug use should receive brief intervention for substance use disorders and be evaluated for combination HIV prevention strategies including PrEP. To investigate the effect of lignin in the cultivar-dependent Cd detoxification of Brassica chinensis L., Cd and lignin contents, lignin composition and laccase genes expressions in low-Cd-accumulating (LAJK) and high-Cd-accumulating (HAJS) cultivars grown under control (CK) and 25 μM Cd-treatment were determined. The results showed that lignin combined about 14 % of total Cd in both LAJK and HAJS. LAC genes were more up-regulated in HAJS than in LAJK, indicating that the LAC genes were involved in the cultivar-dependent lignin functions. Higher β-aryl ether (A) proportion in the lignin side chain region in LAJK than in HAJS were observed, whereas resinol (B) and phenylcoumaran (C) constitute much higher proportions in HAJS than in LAJK. Chemical calculation to estimate Cd affinity associating with lignin side chain region displayed that i) β-aryl ether (A) exhibited major coupling with lignin aromatic region; ii) resinol (B) and phenylcoumaran (C) displayed major participation in complexation with Cd. We therefore conclude that Cd compartmentalization in the secondary cell wall (SCW) by coupling with lignin side chain region is responsible for Cd detoxification related to cultivar-dependent Cd accumulation of Brassica chinensis. This is the first study on lignin composition in relation to Cd retention mechanisms in SCW. Plasma-treated goethite nanoparticles with high surface area and improved density of surface hydroxyl groups were synthesized from natural goethite (NG) using Argon (PTG-Ar) and Nitrogen (PTG-N2) as plasma environment to enhance the performance of heterogeneous catalytic ozonation process. Synthesized samples were characterized by FESEM, EDX, TEM, XRD, XPS, BET-BJH, FTIR, AAS and pHPZC. Results indicated a significantly different morphology for the prepared samples with negligible change in crystal structure. Furthermore, the catalytic activity and synergy factor of the NG and PTG nanocatalysts were evaluated for degradation and mineralization of Sulfasalazine antibiotic (SSZ) as an environmental hazardous contaminant. The highest removal efficiency was achieved 96.05 % under the optimal operating conditions. The kinetic study confirmed the pseudo-first-order reaction for the degradation process. Moreover, the dissolved ozone concentration and effect of organic and inorganic salts were studied in order to assess the reactive oxidant species (ROSs) and catalyst active sites in the process. The mechanism investigation showed the catalytic ozonation of SSZ was mainly performed by successive attacks of hydroxyl radicals (•OH), superoxide radicals (O2-) and direct ozone molecules. Environmentally-friendly modification of the NG, negligible iron leaching, successive reusability and superior catalytic activity are the major benefits of the PTG nanoparticles.