Burnett Mccarthy

The immune system is a potent defense mechanism regulating tumor development and progression. However, immune cells are often functionally compromised in cancer patients, and tumor rejection does not follow successful induction of a CTL response. This is, in part, due to the existing conflict between the tumor system and an unfavorable tumor…[Read more]

Polysaccharides are the most abundant bioactive compounds in Ganoderma and have been widely used as dietary supplements in traditional Chinese medicine for thousands of years. Polysaccharides from Ganoderma exhibit unique biological properties, including anti-tumor, anti-inflammatory, and immunomodulatory activities. Herein, the sources and…[Read more]

The ongoing clinical trials will provide clearer information on efficacy, strength and safety of these molecules. The purpose of this review is to analyze the available evidence and future prospects of SGLT2 inhibitors, which could be widely used in nephrology clinical practice.Early in 2020, racehorse doping cases revolved around the…[Read more]

Exposure to secondhand smoke (SHS) during pregnancy can cause pregnancy complications and adverse birth outcomes. About 40% of Chinese expectant fathers are smokers and they rarely attempt to quit smoking. There is a paucity of effective smoking cessation services targeting this population. In this study, we assessed the smoking behavior of…[Read more]

Calcium (Ca2+) influx into mitochondria occurs through a Ca2+-selective uniporter channel, which regulates essential cellular processes in eukaryotic organisms. Previous evolutionary analyses of its pore-forming subunits MCU and EMRE, and gatekeeper MICU1, pinpointed an evolutionary paradox the presence of MCU homologs in fungal species devoid of…[Read more]

In order to expand the limited understanding of the genomics of antimicrobial-resistant industrial bacteria, we report the genome sequence of Pluralibacter gergoviae ECO77, a historical contaminant strain of industrial origin. The multireplicon 6.16-Mbp genome of ECO77 consists of a 5.37-Mbp main chromosome, a megaplasmid (605,666 bp), and a l…[Read more]

Strong many-body interactions in two-dimensional (2D) semiconductors give rise to efficient exciton-exciton annihilation (EEA). This process is expected to result in the generation of unbound high energy carriers. Here, we report an unconventional photoresponse of van der Waals heterostructure devices resulting from efficient EEA. Our…[Read more]

Cytology and histopathology were suggestive of primary prostatic adenocarcinoma with cutaneous and subcutaneous metastases. To the authors’ knowledge, these are the first reported cases of prostatic adenocarcinoma skin metastases in dogs with cytologic descriptions.

This study describes and demonstrates the functionalities and application of a…[Read more]

Owing to the lack of awareness, this clinical presentation is often mistaken for other follicular dermatoses, including bacterial folliculitis, pityriasis rubra pilaris, keratosis pilaris, or follicular eczema.Leukemia cutis (LC) is a dermatologic manifestation of leukemia. Its clinical implications for the patient and the biological mechanism…[Read more]

Despite the similarities in tissue tropism and histomorphology, GCA and TAK are two distinct vasculitides that rely on separate disease mechanisms and require disease-specific approaches in diagnosis and management.

GCA and TAK share many clinical features, but there are substantial differences in genetics, epidemiology, disease mechanisms,…[Read more]

Conclusions The study suggested the new chronological boundaries in the scientific and educational heritage of N.I. Pirogov. The developed periodization accurately reflects the beginning of his scientific and pedagogical path in medical education, specifically refers to the period of his work in Germany as a supervisor of professorial candidates…[Read more]

Drug discovery is time- and resource-consuming. To this end, computational approaches that are applied in de novo drug design play an important role to improve the efficiency and decrease costs to develop novel drugs. Over several decades, a variety of methods have been proposed and applied in practice. Traditionally, drug design problems are…[Read more]

One line of research has indicated that directional social cues, such as eye gaze and pointed fingers, increase the salience of spatial locations or objects in a relatively involuntary manner (social cueing effect). A separate line of research has indicated that the compatibility between the body part that is observed by an actor primes and…[Read more]

vements when writing by hand and when drawing, it is vital to maintain both activities in a learning environment to facilitate and optimize learning.Before engaging with the already intensive and still increasing personal branding activities in many fields of practice, a scholarly approach would call for a more specific definition of the concept…[Read more]