Bruun Richmond

OBJECTIVE To determine preference-based (utility) assessments of health-related quality of life (HRQoL) in kidney stone patients, and evaluate the association between these and disease specific, psychometric health status-based HRQoL scores (obtained via the Wisconsin Stone Quality of Life [WISQOL]). METHODS One hundred four adults with…[Read more]

Collectively, the data suggest a novel mechanism that IAV stimulates mTOR pathway at early stages of infection; however, at a later time-point, positive regulation of miR-101 restrains the mTOR expression, and hence, the viral propagation.Our previous study demonstrated that a vegetable oil consisting of soybean oil, vitamin E, and ginseng…[Read more]

Objective This study investigated the safety and tolerability of lifastuzumab vedotin (DNIB0600A) (LIFA), an antibody-drug conjugate, in patients with recurrent platinum-sensitive ovarian cancer (PSOC). Methods In this open-label, multicenter phase 1b study, LIFA was administered intravenously once every 3 weeks (Q3W) with starting dose 1.2 mg/kg…[Read more]

Recently, HLA epitopes on donor HLA molecules have been shown to be important in the success of solid organ transplantation. However, these epitopes can only be defined using high resolution typing results of which are often not available prior to deceased donor allocation. The ability to perform high resolution typing at all HLA loci for deceased…[Read more]

Historically, surgical techniques were governed by specific incisions and surgical designs. With the advent of anesthesia, the complicated cases were managed but at the cost of the tissues leading to morbidities of various degrees. The innovations and the advances in the surgical techniques led to the ideology that surgeries could be done with…[Read more]

Results The providers’ overall average score was 50.6% on the SEGUE communication tasks. They did well in ‘Set the stage’ (54.4%) and ‘Elicit information’ (56.2%) but performed poorly in ‘End the encounter’ (24.5%) and ‘Understand the patient’s perspective’ (44.0%). Female and younger providers scored 0.75 (P less then 0.05) and 0.04 (P less then…[Read more]

Elevated circulating concentrations of lipoprotein(a) [Lp(a)] is strongly associated with increased risk of atherosclerotic cardiovascular disease (CVD) and degenerative aortic stenosis. This relationship was first observed in prospective observational studies, and the causal relationship was confirmed in genetic studies. Everybody should have…[Read more]

INTRODUCTION Because improved competence in caring for patients is difficult to measure, self-efficacy (the strength of one’s belief in one’s ability to complete a task) is often used as a surrogate measurement of clinical ability. However, studies in adults and children have shown at best only weak correlations between self-efficacy and…[Read more]