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oleoresins may represent a future source for the discovery of new antimycobacterial drugs due to their low MIC values.Albert Roger Milla speaks to Joseph Martin, Managing Editor Milla is a former international football player for the Cameroon national team. More recently he is the president of the Noma Fund, an association aiming to completely eradicate Noma disease created by Milla, Joseph-Antoine Bell and Georges-Barthélémy Nko’Ayissi. Find out more about the disease, the association and the president behind the project in this interview.

We aimed to investigate

gene expression pattern and to explore its methylation heterogeneity in chronic lymphocytic leukemia (CLL).

Eighty one CLL patients and 75 healthy subjects were enrolled and prognostic evaluation of patients was assessed.

q-realtime PCR was performed using Applied Biosystems, TaqMan gene expression assay.

gene-specific CpG methylation was investigated in real time using pyrosequencing technology.

was differentially expressed in CLL patients. The CpG sites-1, 2 and 3 showed significantly higher mean levels than healthy controls (p=<0.001, 0.007 and 0.009). Significant association between CpG site-1 and CLL has been detected using age-adjusted logistic regression (p<0.001).

Hypermethylation at

gene CpG sites (1,2,3) is a characteristic feature in CLL.

Hypermethylation at ITGA4 gene CpG sites (1,2,3) is a characteristic feature in CLL.

We examined the utility of the rs924607 TT genotype of the

(

) as a potential biomarker for predilection toward vincristine-induced peripheral neuropathy in children treated for acute lymphoblastic leukemia.

We conducted a random-effects meta-analysis of data from four studies comprising 817 patients. We tested for an association using a recessive model where a one-sided p-value <0.05 was considered statistically significant.

We were unable to confirm the association between the rs924607 TT genotype and neurotoxicity (odds ratio 1.99; p=0.16; 95% CI 0.76-5.25) in our global meta-analysis. Analysis of the continuation phase (following induction) studies showed significantly higher odds for neuropathy in

rs924607 TT homozygotes (odds ratio 2.28; p=0.02; 95% CI 1.16-6.87).

We were unable to confirm the association between the rs924607 TT genotype and neurotoxicity (odds ratio 1.99; p = 0.16; 95% CI 0.76-5.25) in our global meta-analysis. Analysis of the continuation phase (following induction) studies showed significantly higher odds for neuropathy in CEP72 rs924607 TT homozygotes (odds ratio 2.28; p = 0.02; 95% CI 1.16-6.87).

Immune-related adverse events are associated with efficacy of immune checkpoint inhibitors (ICIs). We hypothesize that immune-mediated thrombocytopenia could be a biomarker for response to ICIs.

This retrospective study included 215 patients with metastatic malignancies treated with ICIs. Patients were stratified by nadir platelet count. Outcomes of interest were progression-free survival and overall survival.

On multivariate analysis, grade 1 thrombocytopenia was positively associated with overall survival compared with patients who did not develop thrombocytopenia (hazard ratio [HR]= 0.28 [95% CI 0.13-0.60]; p=0.001), while grade 2-4 thrombocytopenia was not (HR=0.36 [95% CI 0.13-1.04]; p=0.060). There was no association between degree of thrombocytopenia and progression-free survival.

Follow-up studies are warranted to substantiate the predictive significance of thrombocytopenia in patients receiving ICIs.

Follow-up studies are warranted to substantiate the predictive significance of thrombocytopenia in patients receiving ICIs.Investment in biomedical research is believed to drive economic growth and increase human capital, leading to increased productivity and sustainability. Unfortunately, such positive impacts are not palpable among the resource-poor countries. This can be attributed to the poor quality of research findings and the reliability of findings, which often are rarely translated to impactful products or decisions. While the Nigerian governments are making considerable efforts to improve the quality of research through increased funding, as well as sponsorship and training of scholars in technologically advanced institutions. This is in order for the transfer of knowledge to improve the livelihood of its citizens. However, there is still need for the private multinational organizations to support this course.We report a Japanese girl with mild xeroderma pigmentosum group D neurological disease. She had short stature, cataracts, intellectual disability, and mild skin symptoms. However, she was not clinically diagnosed. Using whole-exome sequencing, we identified compound heterozygous pathogenic variants in ERCC2. In the future, the patient may develop skin cancer and her neurological symptoms may progress. Early genetic testing is necessary to clarify the cause of symptoms in undiagnosed patients.[This corrects the article DOI 10.1002/nop2.486.].[This corrects the article DOI 10.1002/nop2.403.].

A growing proportion of older people in Germany receive long-term care from informal and professional caregivers at home. Their personal assessment of the individual care situation is scarcely considered.

This study aimed to explore the subjective views of care recipients, informal and professional caregivers on the adequacy of care provision in long-term home care arrangements.

Qualitative semi-structured face-to-face interviews were conducted with ten care recipients, ten professional caregivers and eight informal caregivers to capture their perspectives on the adequacy of the care received and delivered. Qualitative content analysis was applied using MAXQDA software.

All groups highlighted that they perceive an

of care, even though their explanations differed. Selleck PF-04691502 The underprovision was mainly described regarding the quality rather than quantity of services. It occurs especially in interpersonal relationships and social inclusion, where the gap between the self-perceived current situation and the deto the statement that it is currently non-existent or generally impossible. Misprovision of care is experienced as serious whenever the interviewees face the challenge of preserving existing abilities or regaining certain skills.