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Weight fluctuations are common among individuals with obesity and are associated with increased morbidity. We examined adipose tissue immune and inflammatory markers in mice following weight loss and partial weight regain. Male C57BL/6 mice were randomized into four groups (n = 8-10/group) low-fat diet for 32 wk (LFD), high-fat diet for 32 wk (HFD), LFD for 28 wk and then changed to a HFD for 4 wk (LFD→H), and HFD for 21 wk and then changed to LFD for 7 wk and then changed to HFD for 4 wk (HFD→L→H). LFD→H and HFD→L→H mice did not differ in body weight, fat mass, or fat percentage; however, these parameters were greater than in LFD (P less then 0.05) but lower than in HFD (P less then 0.05). HFD→L→H mice had smaller adipocytes than HFD and LFD→H (P less then 0.05) but not LFD mice. Expressions of CD11c and CD8a genes were elevated in epididymal fat of HFD→L→H compared with LFD→H and LFD (P less then 0.05)mice. However, CD11c was lower in HFD→L→H than in HFD mice (P less then 0.05), but there was no ddipose tissue, severity is less than in mice that were exposed to sustained high-fat diet feedings.Early return and increased magnitude of wave reflection augments pulsatile load, wastes left ventricular effort, and is associated with cardiovascular events. Acute handgrip (HG) exercise increases surrogate measures of wave reflection such as augmentation index. However, augmentation index does not allow distinguishing between timing versus magnitude of wave reflection and is affected by factors other than wave reflection per se. Wave separation analysis decomposes central pressure into relative contributions of forward (Pf) and backward (Pb) pressure wave amplitudes to calculate reflection magnitude (RM = Pb/Pf) and determine the timing of apparent wave reflection return. We tested the hypothesis that acute dynamic and isometric HG exercise increases RM and decreases reflected wave transit time (RWTT). Applanation tonometry was used to record radial artery pressure waveforms in 30 adults (25 ± 4 yr) at baseline and during dynamic and isometric HG exercise. Wave separation analysis was performed offline usinometric handgrip exercise. These acute changes in wave reflection during handgrip exercise transiently augment pulsatile load.Skeletal disuse can cause an accumulation of bone marrow adipose tissue (MAT) characterized by a combination of marrow adipocyte hyperplasia and/or hypertrophy. The malleability of MAT accumulation and of the hyperplasia and hypertrophy upon remobilization is unknown. In this study, we showed extensive hyperplasia and accelerated hypertrophy of bone marrow adipocytes in the proximal tibia epiphysis of rat knees immobilized for durations between 1 and 32 wk. Similar histomorphometric measures of adipocytes carried out in unoperated controls allowed distinguishing the effects of immobilization from the effects of aging. Although both knee immobilization and aging led to adipocyte hypertrophy, adipocyte hyperplasia was the hallmark signature effect of immobilization on MAT. Both bone marrow adipocyte hyperplasia and hypertrophy were sustained despite knee remobilization for durations up to four times the duration of immobilization. These results suggest that adipocyte hyperplasia is the predominant mechanism explaining MAT accumulation in skeletal disuse. In this model, the changes were unremitting for the investigated time points. Investigating the cellular and molecular mechanisms of marrow adipocyte mechanoregulation will be important to better understand how adipocytes adapt to changes in mechanical environments.NEW & NOTEWORTHY This longitudinal study elucidates the response of marrow adipose tissue adipocytes in weight-bearing joints to changes in different mechanical environments, and we provide insight on the malleability of the changes over time. In a rat animal model, knee immobilization induced hyperplasia and accelerated the age-dependent hypertrophy of adipocytes. Changes in adipocyte number and size were sustained despite unassisted remobilization. Multimodal distributions of cell size were characteristic of bone marrow adipocytes.Purpose The aim of this study was to provide an in-depth analysis of the prevalence and consequences of within-sport specialization in track and field in the United Kingdom. Method The competition histories of top 100 ranked athletes from four representative events (100 m, 800 m, long jump, and shot put) were recorded from a publically-accessible database. Athletes were drawn from Under 20 (U20), U15, and U13 populations from the 2014/15 season, U15 populations from the 2009/10 season, and U13 populations from the 2007/08 season. Athletes’ specialization status was defined based upon the number of event groups (sprint, endurance, jump, throw) in which they had recorded at least one performance. Chi-squared tests were used to examine the association between level of specialization at U13 and U15 and both performance and retention at subsequent age grades. Results Within-sport specialization was rare among U13 and U15 track and field athletes, with approximately 10% of top 100 ranked U13s and 25% of top 100 ranked U15s competing in a single event group only. However, less than 35% of participants competed in sprinting, endurance running, jumping, and throwing events (i.e., diversification). There were no sex differences in the extent of specialization. Top ranked U20 female athletes were more likely to have diversified at U13 than their peers. There was no association between specialization at U13/U15 and subsequent retention. Conclusion Administrators and coach educators should provide more sophisticated guidance for coaches and parents in relation to within-sport specialization.Detection, identification, and quantification of plant diseases by sensor techniques are expected to enable a more precise disease control, as sensors are sensitive, objective, and highly available for disease assessment. Recent progress in sensor technology and data processing is very promising; nevertheless, technical constraints and issues inherent to variability in host-pathogen interactions currently limit the use of sensors in various fields of application. buy PF-04691502 The information from spectral [e.g., RGB (red, green, blue)], multispectral, and hyperspectral sensors that measure reflectance, fluorescence, and emission of radiation or from electronic noses that detect volatile organic compounds released from plants or pathogens, as well as the potential of sensors to characterize the health status of crops, is evaluated based on the recent literature. Phytopathological aspects of remote sensing of plant diseases across different scales and for various purposes are discussed, including spatial disease patterns, epidemic spread of pathogens, crop characteristics, and links to disease control.