Activity

To evaluate the preference of young adult patients and their willingness to pay for the different approaches accessible to accelerate orthodontic tooth movement. A cross-sectional survey was conducted in Jeddah, Saudi Arabia from September to December 2019. Young adult orthodontic patients from 18 to 45 years old were interviewed via online survey regarding their perception to the extent of treatment, acceptability of non-invasive (customized appliances and medications) and invasive (surgery) approaches accessible to accelerate orthodontic treatment and increase in fees they were willing to pay. Statistical analyses were performed, and gender difference was calculated at P  less then  .05. see more There are 100 respondents 70% aged between 18 to 25, 50% male, and 56% with annual income less then 10 000 SR. About 72% of the respondents decided that treatment takes longer period and 51% wished it would last for less than 6 months. Customized appliances were reported to be the most convenient to use (58%) and to pay (44%), followed by medications (48%). On the other hand, surgery was reported to be the most inconvenient to use (58%) and to pay for (55%). About 70% of the respondents were unwilling to pay more than 10% to 20% for all procedures assessed; considerable variation was not observed in responses between gender at 95% confidence level. Majority of the respondents believed that orthodontic treatment is taking lengthy duration. Less invasive, nonsurgical techniques and procedures were more preferred. Likewise, financial factors play vital role in the selection of their preferred approach. Most of them agrees to provide up to 20% increment of the fee for additional procedures.Linker histone H1 (LHH1) is an abundant nuclear protein that condenses chromatin to form higher-order structure. The present study reported cloning and sequencing of 942 bp of LHH1 from liver tissue of rohu, Labeo rohita, with a complete coding sequence of 792 bp of having 263 amino acids. The phylogenetic tree of L. rohita LHH1 (LrLHH1) shared maximum similarity with that of Carassius auratus. The three dimensional model and domain architecture of LrLHH1 protein was also predicted using Swiss-Prot and SMART domain software. The expression of LHH1 during ontogeny showed significantly higher transcript level in milt, unfertilized eggs and up to 3 h post-fertilization followed by a dramatic decrease thereafter. The tissue-specific expression showed constitutive expression of LrLHH1 in all examined tissues. The expression of LHH1 during different infection models, namely, bacteria (Aeromonas hydrophila); ectoparasite (Argulus siamensis) and poly IC induction revealed modulation in the level of expression at varied time points post-exposure in the liver and anterior kidney tissues of rohu. However, a synthetic peptide derived from LHH1 sequence of rohu did not have any detectable antibacterial activity. The present study provided necessary information on the role of this protein during ontogeny and innate immunity in Indian major carp species.There is a debate about whether and why we overestimate addition and underestimate subtraction results (Operational Momentum or OM effect). Spatial-attentional accounts of OM compete with a model which postulates that OM reflects a weighted combination of multiple arithmetic heuristics and biases (AHAB). This study addressed this debate with the theoretically diagnostic distinction between zero problems (e.g., 3 + 0, 3 – 0) and non-zero problems (e.g., 2 + 1, 4 – 1) because AHAB, in contrast to all other accounts, uniquely predicts reverse OM for the latter problem type. In two tests (line-length production and time production), participants indeed produced shorter lines and under-estimated time intervals in non-zero additions compared with subtractions. This predicted interaction between operation and problem type extends OM to non-spatial magnitudes and highlights the strength of AHAB regarding different problem types and modalities during the mental manipulation of magnitudes. They also suggest that OM reflects methodological details, whereas reverse OM is the more representative behavioural signature of mental arithmetic.

China’s ethics committees alone are unable to meet the growing need for human participant protection. Several scandals in recent years indicate weaknesses in the protection of human participants in China.

The aim of the study is to summarize the status and problems of human research protection program in China and to explore its establishment proposals at national and hospital levels.

To conduct literature retrieval, Chinese National Knowledge Infrastructure, Chinese Biomedical Document Database, and English databases Web of Science and PubMed were searched; laws, guidelines, and regulations were also searched on web by Google and Chinese search engine Baidu.

No data were collected from human participants, and ethical review was not required.

There are problems for China’s Human Research Protection Program, such as weak relevant legal systems, insufficient administrative supervision, and incompetent ethics committee capacities. To fully protect human participants, China should promote the developmenram can strengthen communication and coordination among various hospital departments to effectively protect the rights and welfare of human participants.Modern cattle belong to two subspecies, Bos taurus and Bos indicus. Since divergence, cattle types have accumulated different genetic variations, which have contributed to highly differentiated phenotypes. The mammalian inner ear possesses functional and morphological innovations that contribute to its unique hearing capacities. The spectrin beta, non-erythrocytic 5 (SPTBN5) gene has been shown to play an important function in the inner ear. Four missense mutations rs522333459 (c.7232G > Cp.Cys2411Ser), rs718838405 (c.6568A > Cp.Met2190Leu), rs516536785 (c.6283C > Tp.Leu2095Phe) and rs480278206 (c.4201T > Cp.Cys1401Arg) were identified in the bovine SPTBN5 gene by whole genome resequencing (http//animal.nwsuaf.edu.cn/code/index.php/BosVar), which might be candidate mutations related with hearing of both taurine and indicine cattle. In our study, PCR and DNA sequencing were used to explore the allele frequencies of four mutations of 971 individuals belonging to 38 native Chinese cattle breeds. We find that four mutant alleles showing strong geographic distribution, consisting with the ancestry distribution of taurine and indicine in China.