Activity

Actinometers are physical or chemical systems that can be employed to determine photon fluxes. Chemical actinometers are photochemical systems with known quantum yields that can be employed to determine accurate photon fluxes for specific photochemical reactions. This review explores in detail several practical chemical actinometers (ferrioxalate, iodide-iodate, uranyl oxalate, nitrate, uridine, hydrogen peroxide and several actinometers for the vacuum ultraviolet). Each actinometer is described with recommended conditions for its use.Our study aimed to assess inequities in the clinical trial participation for the selected patient groups. We searched the Food and Drug Administration (FDA) database and extracted phase-III clinical trial data from MEDLINE for each approved drug by the FDA between January 1, 2006, and June 30, 2020. We analyzed the inclusion/exclusion criteria, participation according to gender, ethnic group, performance score, the positivity of HBV and HCV, and HIV, having comorbidities and brain metastasis. We compared the findings with that of the general population by retrieving data from the Surveillance, Epidemiology and End Results (SEER) database. We identified 142 phase III pivotal oncology trials that enrolled 105 397 patients. The proportion of female patients in trials was lower than their relative prevalence in the general population from SEER region (36% vs 49.6%, P less then  .001). The rates of black patients included were lower than their relative prevalence from SEER region (2.1% vs 9.8%, P less then  .001). 1.3% and 0.8% of patients had HBV and HCV infections, respectively. The patients’ numbers with organ dysfunction were not established due to insufficient data from clinical trials. 1.6% of all patients had controlled brain metastasis. Black patients, women and patients with brain metastasis or with HBV and HCV were underrepresented. Our study underscores the importance of expanding the inclusion/exclusion criteria of pivotal oncology trials to be more representative of patients seen in clinical practice.Stress is an important consideration for understanding why individuals take part in limited or no physical activity. The negative effects of stress on physical activity do not hold for everyone, so examinations of possible resilience resources that might protect individuals from the harmful effects of stress are required. Accordingly, we conducted a measurement-burst study with 53 university students over a 6-month period to examine the dynamics among stress, physical activity, sedentary behavior, and resilience resources. Participants completed three bursts of 6 days, with each burst separated by an 8-week gap. Expectations regarding the moderating effects of resilience resources were unsupported. Daily reports of academic and general stress were positively associated with sedentary behavior and negatively associated with light and moderate intensity physical activity. 2-Aminoethyl Hair cortisol concentration significantly moderated the association between academic stress and sedentary behavior, such that in bursts where cortisol was lower the daily positive association between stress and sedentary behavior was weaker. The finding that academic and general stress are dynamically associated with lower levels of light and moderate intensity physical activity and higher levels of sedentary behavior is an important extension to previous research, which has relied mainly on cross-sectional designs and self-report methods. Future research might examine resilience resources that are specific to the outcomes of interest rather than rely on generic resources.Using a long-term prospective longitudinal study of U.S. men and their fathers, the present study examined the extent to which the quantity (i.e., shared activities between fathers and sons) and the quality (i.e., assessors’ ratings of fathers’ positive behaviors toward sons and the relationship quality between fathers and sons) of father involvement during childhood influenced sons’ diurnal patterns of salivary cortisol in adulthood (late 30s) directly and indirectly through substance use across the 20s. Findings indicated that the quantity of father involvement during childhood was directly associated with sons’ diurnal cortisol patterns assessed almost 30 years later. Specifically, the quantity of father involvement in childhood significantly increased the intercept (i.e., upon awakening) and also led to a greater reduction in cortisol across the day, suggesting a well-regulated diurnal cortisol pattern. The quantity of father involvement significantly reduced the amount of sons’ illicit drug and tobacco use across the 20s. Tobacco use across the 20s was associated with a lower cortisol intercept level (upon awakening), although the mediating path was not significant. The present study provided empirical evidence demonstrating long-term physiological and behavioral consequences of father involvement in childhood and its potency as a crucial early caregiving environment for sons.Chordomas are primary bone tumors that arise in the cranial base, mobile spine, and sacrococcygeal region, affecting patients of all ages. Currently, there are no approved agents for chordoma patients. Here, we evaluated the anti-tumor efficacy of small molecule inhibitors that target oncogenic pathways in chordoma, as single agents and in combination, to identify novel therapeutic approaches with the greatest translational potential. A panel of small molecule compounds was screened in vivo against patient-derived xenograft (PDX) models of chordoma, and potentially synergistic combinations were further evaluated using chordoma cell lines and xenograft models. Among the tested agents, inhibitors of EGFR (BIBX 1382, erlotinib, and afatinib), c-MET (crizotinib), and mTOR (AZD8055) significantly inhibited tumor growth in vivo but did not induce tumor regression. Co-inhibition of EGFR and c-MET using erlotinib and crizotinib synergistically reduced cell viability in chordoma cell lines but did not result in enhanced in vivo activity. Co-inhibition of EGFR and mTOR pathways using afatinib and AZD8055 synergistically reduced cell viability in chordoma cell lines. Importantly, this dual inhibition completely suppressed tumor growth in vivo, showing improved tumor control. Together, these data demonstrate that individual inhibitors of EGFR, c-MET, and mTOR pathways suppress chordoma growth both in vitro and in vivo. mTOR inhibition increased the efficacy of EGFR inhibition on chordoma growth in several preclinical models. The insights gained from our study potentially provide a novel combination therapeutic strategy for patients with chordoma. © 2021 The Authors. The Journal of Pathology published by John Wiley & Sons, Ltd. on behalf of The Pathological Society of Great Britain and Ireland.