Klemmensen Hayes

In vivo application of siRNA formulation to SKH-1E hairless mice significantly suppressed Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) expression with no clinical evidence of toxicity. This strategy suggests a simple, personalized, and scalable platform for effective topical delivery of RNAi for treating genetic skin diseases. V.Cannabis is…[Read more]

Neuromodulators regulate higher-order cognitive processes including learning and memory through modulation of synaptic transmission and plasticity. Norepinephrine is a neuromodulator that is secreted throughout the brain in response to novelty or increased arousal, which alters neural circuits by increasing the modifiability of CNS synapses.…[Read more]

727, 71.7%, and 75.2%, respectively, which were significantly higher than those of conventional US (Z = -2.403; P = .016; Z = -5.330; P  less then  .001; and Z = -2.390; P = .017). The specificity of the model was 73.7%, which was lower than that of conventional US (Z = 3.508; P  less then  .001). CONCLUSIONS The preoperative prediction model e…[Read more]

Although conventional homoepitaxy forms high-quality epitaxial layers1-5, the limited set of material systems for commercially available wafers restricts the range of materials that can be grown homoepitaxially. At the same time, conventional heteroepitaxy of lattice-mismatched systems produces dislocations above a critical strain energy to…[Read more]

Bayesian modelling estimated the sensitivity and specificity of the MAT as 96.2% (95% credible interval 91.8-98.8) and 82.1% (64.9-93.6), and qPCR as 90.1% (83.6-95.5) and 96.0% (82.1-99.8), respectively. True prevalence of T. gondii infection in feral cats on Phillip Island was estimated as 90.3% (83.2-95.1). Multivariable logistic regression…[Read more]