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05) . The serum levels of leptin in patients with second stage and third stage silicosis were higher than those in the control group and first stage, the differences were statistically significant (P less then 0.05) . Serum levels of TGF-β1 in all stage silicosis patients were higher than those in the control group, and third stage silicosis was higher than first stage, the differences were statistically significant (P less then 0.05) . There was a positive correlation between serum levels of leptin and TGF-β1 in silicosis group (r(s)=0.400, P less then 0.05) . The ROC area of leptin and TGF-β1 combined to predict silicosis was 0.826, with the sensitivity and specificity were 73.10% and 80.00%. Conclusion The levels of serum leptin and TGF-β 1 are related to different stages of silicosis, and the combined detection of leptin and TGF-β 1 can assist the diagnosis of silicosis.Objective To explore the application of the Short Form of Quality of Life (SF-36) scale in the investigation of quality of life of occupational disease patients. Methods In May 2019, SF-36 scale was used to investigate the occupational disease patients diagnosed in Hangzhou. The reliability of the scale was evaluated by Cronbach’s α coefficient, and the validity of the scale was evaluated by exploratory factor analysis. Results The Cronbach’s α coefficients of PF, RP, BP, GH, VT, SF, RE and MH were 0.937, 0.977, 0.870, 0.908, 0.815, 0.701, 0.967 and 0.863 respectively, and the half reliability coefficient α=0.905. The two factor statistics representing physiological and psychological aspects were 0.870, and the approximate chi square value was 1784.337 (P less then 0.01) . Compared with the national norm, the scores of each dimension of quality of life of occupational disease patients were significantly lower, and the differences were statistically significant (P less then 0.01) ; Compared with the scores of each dimension of quality of life of pneumoconiosis patients, the scores of PF, RP and GH of occupational disease patients were significantly higher, and the differences were statistically significant (P less then 0.05) . Conclusion SF-36 scale has good reliability and validity in measuring the quality of life of patients with occupational diseases, which can be used to evaluate the quality of life of patients with occupational diseases.Objective To explore the effect of occupational nickel exposure on blood glucose related indicators of workers. Methods In March 2019, five electroplating enterprises and one plastic hardware enterprise were selected by cluster sampling method. Seladelpar chemical structure 159 nickel plating workers were selected as the contact group, and 66 administrative personnel of the same enterprise were selected as the control group. The serum nickel concentration, fasting blood glucose (FPG) , fasting insulin (FIns) and glycosylated hemoglobin (HbA1c) were measured in the contact group and the control group. The differences of blood glucose related indexes between the two groups were compared, and the risk factors of abnormal blood glucose indexes were analyzed. Results Compared with the control group, the blood nickel concentration and detection rate of nickel in the contact group were higher, the levels of FIns were lower, and the proportion of HbA1c was higher in the contact group (P less then 0.05) . Stratified analysis showed that compared with the control group, the blood glucose index of men in the contact group changed significantly (P less then 0.05) ; logistic regression analysis showed that male was an independent influencing factor for decreased FIns (OR=8.264, P less then 0.05) . Conclusion Long term exposure to nickel can affect the blood glucose related indexes such as fins and HbA1c.Objective To explore the relationship between occupational stress and metabolic syndrome (MS) in operating room nurses. Methods In July 2019, 179 nurses in the operating room of a third-class A hospital in Shandong Province were selected as the research objects. The self-designed questionnaire was used to investigate the general situation, and “Nurse Job Stressor Scale” was used to investigate the occupational stress level of nursing staff. The height, weight, waist circumference, blood pressure, fasting blood glucose, total cholesterol, triglycerides, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, ischemia-modified albumin, lipoprotein associated phospholipase A2 were measured. The nursing staff were divided into MS group and non-MS group, and the occupational stress levels of the two groups were compared. Chi square test or Fisher test were used to compare the counting data between groups; the measurement data were expressed by Mean±SD, and the comparison between groups was perfos level of nurses in operating room is related to the prevalence of MS.Objective To explore the psychological status of medical staff during COVID-19 epidemic, so as to provide reference and scientific basis for carrying out further psychological intervention and ensuring the mental health of medical staff. Methods By using convenient sampling method and the Stresss-Anxiety ubscale of Depression Anxiety Stress (DASS-21) , the mental health status of 615 medical staff was investigated by the way of questionnaire star from February 4 to 16, 2020. A total of 615 questionnaires were distributed and collected, and 615 were valid, with an effective recovery rate of 100%. Results The detection rates of psychological stress and anxiety of medical staff were 13.82% (85/615) and 25.37% (156/615) , respectively. 31-40 years old and working in key departments were risk factors for psychological stress of medical staff (OR=1.779, 2.127) ; Women, frequently washing hands with soap/hand sanitizer/disinfectant were protective factors for psychological stress (OR=0.520, 0.528) . Medical staff working in designated hospitals and key departments were more likely to have anxiety (OR=2.042, 2.702) ; The high fit of the mask to the face and bridge of the nose was a protective factor for the psychological anxiety of medical staff (OR=0.500) . Conclusion Medical staff show higher stress and anxiety during the epidemic of COVID-19. Psychological intervention should be carried out early, focusing on men, age 31 to 40, medical staff working in designated hospitals and key departments.