Activity

To understand patients’ qualitative experiences with the Support, Educate, Empower (SEE) personalized glaucoma coaching program, provide a richer understanding of the components of the intervention that were useful in eliciting behavior change, and understand how to improve the SEE Program.

A concurrent mixed-methods process analysis.

Thirty-nine patients with a diagnosis of any kind of glaucoma or ocular hypertension who were aged ≥40 years, were taking ≥1 glaucoma medication, spoke English, self-administered their eyedrops, and had poor glaucoma medication adherence (defined as taking ≤80% of prescribed medication doses assessed via electronic medication adherence monitors) who completed the 7-month SEE Program.

All participants who completed the study were interviewed in-person using a semistructured interview guide after the intervention. Coders conducted qualitative analysis of transcribed interviews using Grounded Theory. Participants were then stratified into groups based on change in adherenced personal need to improve adherence.

Participants reported a highly positive response to the in-person glaucoma education and motivational interviewing intervention used in conjunction with automated adherence reminders.

Participants reported a highly positive response to the in-person glaucoma education and motivational interviewing intervention used in conjunction with automated adherence reminders.Gender differences in language can be signs of cognitive differences, but can also by themselves be the cause for such differences. Females have a slight linguistic advantage over males, but effect sizes are small, and gender explains very little of the variance seen in the normal population (1%-2%). However, males outnumber females in the lowest 10th percentile in language tests (21), causing males to more often be diagnosed with developmental disorders, which rely on tests of language development. Thus, gender differences in language are negligible, if you focus on the whole population, but if you focus on language deficits, gender differences are outspoken. Differences in voice and word use can be observed among the genders, making it possible to predict gender from these measures with a high degree of certainty. MRTX849 purchase A subtle finding is that women use more first person pronouns. This is also observed in depression, which is more prevalent in females, opening up a potential link. Sex chromosome trisomies are often accompanied by language deficits, but the causes for this are not known. No gender differences are observed in the linguistic symptoms of neurodegenerative disorders. Poststroke aphasia is more prevalent among women than among men, but this seems to be an age-effect. A link between the brain and gender differences in language is thus missing.Spatial skills represent an important part of our cognitive processes and have been widely studied in the last decades. The term “spatial skills” includes several abilities, some of them clearly sexually dimorphic. Thus men usually perform better than women in mental rotation and spatial orientation tasks, whereas women outperform men in object location memory tests. Skills like visualization and perception could account for these differences, but they could also be modulated by the cognitive style. Obviously, disease can interfere in certain brain structures underlying learning and memory, thus altering spatial abilities in both genders. In this chapter, spatial skills and sexual dimorphism are briefly reviewed, focusing on processes underlying performance as well as models used to explain how we perceive information from the environment. The chapter also includes references to the brain, providing some cues regarding the anatomic regions underlying some of these behaviors.Stress is associated with the onset of several stress-related mental disorders that occur more frequently in women than in men, such as major depression or posttraumatic stress disorder (PTSD). The hypothalamic-pituitary-adrenal (HPA) axis is the major component of the neuroendocrine network responding to internal and external challenges. The proper functioning of the HPA axis is critical for the maintenance of mental and physical health, as dysregulations of the HPA axis have been linked to several mental and physical disorders. Numerous studies have observed distinct sex differences in the regulation of the HPA axis in response to stress, and it is supposed that these differences may partially explain the female predominance in stress-related mental disorders. Preclinical models have clearly shown that the HPA axis in females is activated more rapidly and produces a larger output of stress hormones than in males. However, studies with humans often produced inconsistent findings, which might be traced back to the variation of investigated stressors, the use of contraceptives in some of the studies, and different menstrual cycle stages of the female subjects. This article discusses rodent and human literature of sex differences in the function of the HPA axis.Sex and gender are increasingly recognized as major influencing factors in disorders across all medical specialties. Even though there is ample evidence of sex and gender differences in neuropsychiatric disorders, a sex and gender-differentiated approach has not yet been sufficiently applied to diagnostics and management. Therefore, there is an urgent need to establish general recommendations and guidelines toward precision and sex/gender medicine, with regard to dosage, tolerability, interactions and side effects, sensitivity of diagnostic tests, and distinct treatment strategies. This chapter illustrates the current knowledge about sex and gender aspects in neuropsychiatric disorders, providing a base not only to assist the clinician in the handling of specific pathologic entities, but also to sensitize medical practitioners to consider sex and gender in clinical decision-making. As such, the chapter is a call to action to physicians and researchers to produce more sex- and gender-stratified evidence, leading to an acceleration of guideline development. Such novel guidelines will provide a base for medical education, of both medical students and specialists, as well as a reference point for practitioners, toward precision medicine.