Lykke Kennedy

reports. In addition, the effect on splicing in a minigene assay of a novel splice site variant in the NHS gene (c.[719-2A>G]) supported the pathogenicity of this variant.

This study emphasizes the importance of genetic testing of congenital cataracts. Known dominant genes need to be considered for recessive inheritance patterns. Syndromic…[Read more]

To this end, a Geographical Information Systems (GIS) based framework is outlined to facilitate the analysis of the morphological characteristics of hot spots over time. The analysis framework is applied to a case study of vehicular accidents reported over a two-year period to demonstrate its practical utility. The application results indicate…[Read more]

patient selection for prospective clinical trials in OM prostate cancer.

Immunotherapy is effective in a small percentage of patients with cancer and no reliable predictive biomarkers are currently available. Artificial Intelligence algorithms may automatically quantify radiologic characteristics associated with disease response to medical…[Read more]

Finally, we summarize the properties and functions of currently available public resources for exploring the mouse gut microbiota.Analysis of calorimetric and crystallographic information shows that the α-helix is maintained not only by the hydrogen bonds between its polar peptide groups, as originally supposed, but also by van der Waals…[Read more]

hopedic practices.

Prescription opioid misuse represents a social and economic challenge in the United States. We evaluated Schedule II opioid prescribing practices by primary care providers (PCPs), orthopedic and general surgeons, and pain management specialists.

Prospective evaluation of prescribing practices of PCPs, orthopedic and…[Read more]

The main message to consumers is to choose Salmonella-free eggs (those that some official entity or producer guarantees that does not contain Salmonella), when available, especially for dishes that are not fully heat treated. Second, as guaranteed Salmonella-free eggs are only available in a few countries, refrigerated storage from the point of…[Read more]

001), with improvements maintained or increased at week 52 (p<0.001). There was no significant interaction between ECRS subgroup (non-/mild or moderate/severe) and dupilumab treatment effect for all endpoints at weeks 24 and 52 (p>0.05), except LMK-CT at week 24 (p=0.0275). Similar results were seen for the secondary endpoints. Dupilumab was well…[Read more]

Adherence to regular, thorough skin self-examination (SSE) and consistent sun protection behaviors among melanoma survivors is relatively low. This study reports on the impact of an online intervention, called mySmartSkin (MSS), on engagement in SSE and sun protection behaviors among melanoma survivors, as well as the mediators of the intervention…[Read more]

Radiologic imaging proves diagnostic in most cases. Despite the somatic type malignancy, surgical excision of the tumour using the en-bloc technique seems to be a sufficient option for the patient, and further oncological treatment is not always obligatory.

Radiologic imaging proves diagnostic in most cases. Despite the somatic type malignancy,…[Read more]

Hedgehog signaling is essential to the regulation of embryonic development, tissue homeostasis, and stem cell self-renewal, making it a prime target for developing cancer therapeutics. Given the close link between aberrant Hedgehog signaling and cancers, many small molecular compounds have been developed to inhibit Smoothened, a key signal…[Read more]