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0 and 94.1% at 5 years, respectively) than those with thicker NAM (58.3 and 55.6% at 5 years, respectively). A total of 53.3% of 30 patients underwent primary excision and covering with a full-thickness skin graft, while 13.3% of our 30 patients underwent digit amputation. The patients who underwent excision and covering with a full-thickness skin graft showed a complete overall survival (100% at 5 years).

Primary tumor location in the hand and lower tumor thickness might be correlated with better patients’ survival. The study results suggest that total amputation might not be necessary in all NAM cases.

Primary tumor location in the hand and lower tumor thickness might be correlated with better patients’ survival. The study results suggest that total amputation might not be necessary in all NAM cases.The detachment of cells from the boundary of an epithelial tissue and the subsequent invasion of these cells into surrounding tissues is important for cancer development and wound healing, and is strongly associated with the epithelial-mesenchymal transition (EMT). Chemical signals, such as TGF-β, produced by surrounding tissue can be uptaken by cells and induce EMT. In this work, we present a novel cell-based discrete mathematical model of mechanical cellular relaxation, cell proliferation, and cell detachment driven by chemically-dependent EMT in an epithelial tissue. A continuum description of the model is then derived in the form of a novel nonlinear free boundary problem. Using the discrete and continuum models we explore how the coupling of chemical transport and mechanical interactions influences EMT, and postulate how this could be used to help control EMT in pathological situations.In this study, a cyclodextrin derivative (R6RGD-CMβCD) nanoparticle with tumor targeting and cell penetration ability was successfully synthesized and loaded with tyroserleutide (YSL) to obtain YSL-loaded nanoparticles (YSL/R6RGD-CMβCD NPs). The characterization of these NPs revealed a smooth surfaces and an average diameter of approximately 170 nm. YSL/R6RGD-CMβCD NPs increased the NP uptake in Caco-2 cells. As regard the mechanism of action, the cell uptake was related to endocytosis mediated by reticulin and megacytosis. see more In addition, YSL/R6RGD-CMβCD NPs induced significantly higher cytotoxicity on tumor cells and better tumor targeting compared with the effect of CMβCD NPs. Most importantly, the good anti-cancer effect of YSL/R6RGD-CMβCD NPs might be due to the interference with the function of mitochondria. On the other hand, YSL/R6RGD-CMβCD NPs were not toxic for normal cells. Taken together, our results indicated that R6RGD-CMβCD could be considered as a nanopharmaceutical material with good tumor targeting abilities, and their combination with YSL could represent an effective anti-cancer system.The objective of the present study was to evaluate the intensity and spatial distribution of scattered radiation caused by the use of hand-held x-ray equipment in the zone occupied by the operator using the Monte Carlo simulation for radiographic views of the upper and lower incisor teeth and the consequent evaluation of the equivalent dose in the lens. In order to carry out this evaluation, the geometry of a typical dental facility with plaster walls containing the scattering object was used for the computational scenario implemented for the Monte Carlo method simulation. The PENELOPE code for Monte Carlo simulation of electron and photon transport was used with the radiation beam represented by a 60 kV spectrum; 1.5 mm Al and tungsten target. The simulations were carried out with typical parameters for workload and the number of radiographs/week. The results demonstrated that the exposure levels varied significantly according to the angle of the x-ray beam and with the distance to the scattering object. It is concluded that the incorporation of hand-held equipment in dental radiology must be accompanied by surveillance of occupational exposure levels and a review of the training structure of professionals in dental radiology regarding aspects of radiological protection and the particularities of using this type of equipment.Replicating the functionality of the human eye has been a challenge for more than a century, creating a great wealth of biomimetic and bioinspired devices, and providing ever improving models of the eye for myriad research purposes. As improvements in microelectronics have proceeded, individual components of the eye have been replicated, and models of the optical behaviour of the eye have improved. This review explores both work developed for improving medical components, with an ultimate aim of a fully functioning prosthetic eye, and work looking at improving existing devices through biomimetic means. It is hoped that this holistic approach to the subject will aid in the cross pollination of ideas between the two research foci. The review starts by summarising the reported measurements of optical parameters of various components of the eye. It then charts the development of individual bionic components. Particular focus is put on the development of bionic and biomimetic forms of the two main adaptive components of the eye, namely the lens and the iris, and the challenges faced in modelling the light sensitive retina. Work on each of these components is thoroughly reviewed, including an overview of the principles behind the many different approaches used to mimic the functionality, and discussion of the pros and cons of each approach. This is concluded by an overview of several reported models of the complete or semi-complete eye, including details of the components used and a summary of the models’ functionality. Finally, some consideration is given to the direction of travel of this field of research, and which existing approaches are likely to bring us closer to the long term goal of a fully functional analogue of the eye.We present the studies of structural and magnetic properties of graphene composites prepared with several quantities ofα-Fe2O3dopant of 5%, 25% and 50% made with either ethanol or acetone. Our studies showed the presence of a weak magnetic order up to room temperature and saturation magnetization close to 0.2 emu g-1in pure commercial graphene. With regard to magnetic properties of our graphene + iron oxide samples, the solvent used during the preparation of the composite had a significant influence on them. For graphene + Fe2O3samples made with acetone the magnetic properties of pure graphene played a major role in the overall magnetic susceptibility and magnetization. On the other hand, for graphene + iron oxide samples made with ethanol we observed the presence of superparamagnetic blocking atT less then 110 K which was due to the additional appearance ofγ-Fe3O4nanoparticles. Changes in the synthesis solvent played a major role in the magnetic properties of our graphene + Fe2O3nanocomposite samples resulting in much higher saturation magnetization for the samples made with ethanol.