Salisbury Silver

The development of biomechanical models of the torso and the spine opens the door to computational solutions for the design of braces for adolescent idiopathic scoliosis. However, the design of such biomechanical models faces several unknowns, such as the correct identification of relevant mechanical elements, or the required accuracy of model…[Read more]

The major barriers to mesenchymal stem cell (MSC) therapy in rheumatoid arthritis (RA) are a low extent of tissue regeneration and insufficient immunomodulation after cell transplantation. In addition, the role of C-X-C chemokine receptor type 7 (CXCR7) and its mechanism of action in MSC-mediated osteogenic or chondrogenic differentiation and…[Read more]

The new model significantly improved the diagnostic accuracy of PCa (0.945 vs 0.830, P less then 0.01) and csPCa (0.937 vs 0.845, P less then 0.01) compared with the base model. In addition, the number of patients with PCa and csPCa predicted by the new model was in good agreement with the actual number of patients with PCa and csPCa in high-risk…[Read more]

Conversely, some larger centers opted to continue routine transplant activity in order to balance waiting list mortality. To model these and other ethical tensions, we computed a QE score using 4 factors – Recipient Outcome, Donor/Graft Safety, Waiting List Mortality and Healthcare Resources for seven countries. The fluctuation of the QE score…[Read more]