Activity

To achieve carbon neutrality, the Korean government has promoted regulatory policies on the transition toward a carbon free economy in 2050. Unfortunately, these policies face strong complaints from industries with respect to losing international competitiveness owing to extra cost burdens. Is it feasible to achieve a carbon neutral economy with these regulatory policies? This study tries answering the question by evaluating the CO2 emissions performances of the Korean manufacturing industry for feasible solutions toward a carbon neutral economy. 7,12-Dimethylbenz[a]anthracene price For this purpose, we adopted the metafrontier Malmquist-Luenberger (MML) index to reflect group heterogeneity at the technology level. Forty subsectors of manufacturing industrial data were collected from 2012 to 2017, which were classified under four technological levels high, middle-high, middle-low, and low. The CO2 emissions performance showed a poor effect from the policies, with an overall 0.8% deterioration (-0.8%) in the CO2 emissions. Under the group heterogeneity, the middle-high and middle-low technology groups showed a significantly slower upward trend, implying that the environmental regulatory regime did not have a strong effect on these groups. To obtain a feasible solution for this fine tuning, MML decomposition was implemented in the second stage. As the efficiency change is the main driver that influences the CO2 emissions performance, the Korean government should encourage the catching-up effect in industries via a green cultural revolution, as well as provide strong incentives to avoid negligible performance in the innovation effect, supported by more market-oriented emissions trading schemes (ETSs).Abundance of plastic waste has become threat to the mankind and aquatic life and thus needs to be recycled or converted into value added products. Liquefaction of waste plastics via catalytic cracking is one the efficient routes towards plastic waste management. Concerning this, in present study, conversion of polymer mixture containing polypropylene, low-density polyethylene and high-density polyethylene (PP, LDPE and HDPE) was done for the production of gasoline and diesel range hydrocarbons using two-step cracking approach. MWW and MFI (12 and 10 member ring structures respectively) type zeolites having different pore structure and acidity were used for catalytic cracking of polymer feed at 350 °C. Investigations revealed that MWW type zeolite having two independent pore channels selectively provides gasoline range of hydrocarbons (C7-C12, 99.12%) in polymer cracking reaction as compared to MFI type which results in C13-C20 range of hydrocarbons (73.19%). Hydrocarbon compositions were confirmed from GC-MS, 1H, 13C NMR and FT-IR techniques. In activity results it was observed that acidity of zeolites affects the liquid yield and hydrocarbon distribution as analysed by using zeolites of two different SiO2/Al2O3 (SAR) ratio (30 and 55) which directs that zeolite (MFI/MWW) with lower SAR (30) having higher acidity results in higher yield of fuel range liquid hydrocarbons as compared to higher SAR (55) zeolite. Characterization studies such as XRD, N2-physisorption, NH3-TPD, FE-SEM and EDX were performed to check the physiochemical properties of zeolite and correlated with the activity. Overall, the present investigation provides detailed comparative study on plastic degradation using MFI and MWW type zeolites resulting into different range of liquid hydrocarbons.In this work the presence of different pharmaceuticals at Doñana National Park (Spain) and their main entry sources (input source or entry points) have been stated over the 2011-2016 years period. Twenty-three selected pharmaceuticals (corresponding to eight therapeutic families) were evaluated in crayfish and water samples from Doñana National Park (Spain) (six sampling points selected in order to cover different possible pollution sources into and surrounding the Park). The multiresidue determination was carried out using enzymatic-microwave assisted extraction prior to high performance liquid chromatography mass spectrometry detection. Sulphonamides (sulfadiazine, sulfamerazine, sulfamethazine, and sulfamethoxazole); trimethoprim, an antibiotic that is frequently co-administered with sulfamethoxazole; amphenicols (chloramphenicol, florfenicol and thiamphenicol); fluoroquinolones (ciprofloxacin, enrofloxacin, flumequine, danofloxacin, gatifloxacin, norfloxacin, marbofloxacin and grepafloxacin); penicillins (amoxicillin); tetracyclines (chlortetracycline and oxytetracycline); non-steroidal anti-inflammatory drugs (salicylic acid and ibuprofen); beta-blocker drugs (atenolol); and antiepileptics (carbamazepine) were analysed. Ciprofloxacin, ibuprofen, salicylic acid, flumequine, and carbamazepine were detected and/or quantified at some of the selected sampling points. A clear ecotoxicological risk to the ecosystem was demonstrated from the occurrence of ciprofloxacin in samples obtained after the punctual and massive presence of people inside the Park. Furthermore, flumequine and carbamazepine have been detected in Procambarus clarkii specimens in concentrations around 30 ng g-1 and 14 ng g-1, respectively, and their occurrence in the specimens could indicate the persistence of the discharge sources. The main source of pharmaceuticals into the Park might be the livestock farming activities, and the influence of urban wastewaters from surrounding villages does not seem to be very important.The coronavirus disease 2019 (COVID -19) pandemic caused by the novel severe acute respiratory syndrome coronavirus (SARS-CoV-2) has affected almost every country in the world, resulting in severe morbidity, mortality and economic hardship, and altering the landscape of healthcare forever. Although primarily a pulmonary illness, it can affect multiple organ systems throughout the body, sometimes with devastating complications and long-term sequelae. As we move into the second year of this pandemic, a better understanding of the pathophysiology of the virus and the varied imaging findings of COVID-19 in the involved organs is crucial to better manage this complex multi-organ disease and to help improve overall survival. This manuscript provides a comprehensive overview of the pathophysiology of the virus along with a detailed and systematic imaging review of the extra-thoracic manifestation of COVID-19 with the exception of unique cardiothoracic features associated with multisystem inflammatory syndrome in children (MIS-C). In Part I, extra-thoracic manifestations of COVID-19 in the abdomen in adults and features of MIS-C will be reviewed. In Part II, manifestations of COVID-19 in the musculoskeletal, central nervous and vascular systems will be reviewed.With the Pfizer-BioNTech, Moderna, and now Johnson and Johnson COVID-19 vaccines readily available to the general population, the appearance of vaccine-induced axillary adenopathy on imaging has become more prevalent. We are presenting follow up to the first reported four cases of vaccine induced unilateral axillary adenopathy on imaging to our knowledge, which demonstrate expected self-resolving adenopathy. Our hope is that by providing this follow-up and reviewing current management guidelines, clinicians as well as patients will appreciate that this is an expected, benign, and self-resolving finding. In addition, we hope to quell any vaccine hesitancy brought about by recent mainstream media attention to this topic and ultimately empower patients to receive both the COVID-19 vaccine and undergo routine screening mammography, as both are vital to their health.Rituximab (a B-cell depleting monoclonal antibody) is increasingly utilized for treatment of different immune-mediated neurologic disorders, including aquaporin-4-IgG-positive neuromyelitis optica spectrum disorder (AQP4-IgG-NMOSD). After an initial treatment course, the drug is generally reinfused when peripheral blood B-cells levels re-increase >1% (usually after 6-12 months), or at fixed pre-planned 6-month intervals. We describe the unusual case of a 40-year-old woman with AQP4-IgG-NMOSD who showed a prolonged B-cell depletion for nearly five years after a single rituximab reinfusion. In similar rare patients with exceptionally long-lasting B-cell depletion, rituximab reinfusions at fixed pre-planned intervals would result in unnecessary treatment-related risks and health-care expenses.We report the case of a patient with symptoms of anti-NMDAR encephalitis and anti-MOG associated disease simultaneously, in whom the identification of antibodies guided to a more aggressive treatment strategy, resulting in a good clinical outcome. MRI is an important tool to diagnose this kind of patients. The co-occurrence of both diseases in infrequent, but atypical symptoms should increase our awareness of the possibility of an overlap syndrome.

The study investigated the directionality of associations between mental health problems and school grades across two timepoints (T1 and T2) during mid to late adolescence; in school year 9 (ages 15-16) and school year 12 (ages 17-18). The study also investigated variation in the associations as a function of gender and across socioeconomic groups.

Longitudinal data from several Swedish administrative registers were utilised. Information on prescribed psychotropic drugs was used as a proxy for mental health problems, and teacher-assigned school grades were used to measure academic performance. The study sample comprised 85186 individuals (50.7% girls) born in 1991 who were alive and resident in Sweden in 2010. Directions of associations were analysed by estimating a series of cross-lagged path models.

The model with the best fit to data showed that higher school grades at T1 were associated with relatively lower rates of mental health problems by T2, for both boys and girls, mainly in socioeconomic groups with the highest educated parents. This association was equal in size across all of the socioeconomic groups that were explored.

Performing well in school is equally important for boys’ and girls’ subsequent mental health, but only among adolescents in socioeconomic groups with the highest educated parents. The results underscore the importance of promoting opportunities for youth to do as well as they can in school.

Performing well in school is equally important for boys’ and girls’ subsequent mental health, but only among adolescents in socioeconomic groups with the highest educated parents. The results underscore the importance of promoting opportunities for youth to do as well as they can in school.Rats have long been an ideal model for disease research in the field of biomedicine, but the bottleneck of in vitro culture of rat embryonic stem (ES) cells hindered the wide application as genetic disease models. Here, we optimized a special medium which we named 5N-medium for rat embryonic stem cells, which improved the in vitro cells with better morphology and higher pluripotency. We then established a drug selection schedule harboring a prior selection of 12 h that achieved a higher positive selection ratio. These treatments induced at least 50% increase of homologous recombination efficiency compared with conventional 2i culture condition. Moreover, the ratio of euploid ES clones also increased by 50% with a higher germline transmission rate. Finally, we successfully knocked in a 175 kb human Bacterial Artificial Chromosome (BAC) fragment to rat ES genome through recombinase mediated cassette exchange (RMCE). Hence, we provide a promising system for generating sophisticated rat models which could be benefit for biomedical researches.