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The impact of COVID-19 control on air quality have been prevalent for the past two years, however few studies have explored the toxicity of atmospheric particulate matter during the epidemic control. Therefore, this research highlights the characteristics and sources of oxidative potential (OP) and the new health risk substances environmentally persistent free radicals (EPFRs) in comparison to city lockdown (CLD) with early days of 2019-2020. Daily particulate matter (PM2.5) samples were collected from January 14 to February 3, 2020, with the same period during 2019 in Xi’an city. The results indicated that the average concentration of PM2.5 decreased by 48% during CLD. Concentrations of other air pollutants and components, such as PM10, NO2, SO2, WSIs, OC and EC were also decreased by 22%, 19%, 2%, 17%, 6%, and 4% respectively during the CLD, compared to the same period in 2019. Whereas only O3 increased by 30% during CLD. The concentrations of EPFRs in PM2.5 was considerably lower than in 2019, which decreased by 12% during CLD. However, the OP level was increased slightly during CLD. Moreover, both EPFRs/PM and DTTv/PM did not decrease or even increase significantly, manifesting that the toxicity of particulate matter has not been reduced by more gains during the CLD. Based on PMF analysis, during the epidemic period, the contribution of traffic emission is significantly reduced, while EPFRs and DTTv increased, which consist of significant O3 and secondary aerosols. This research leads to able future research on human health effect of EPFRs and oxidative potential and can be also used to formulate the majors to control EPFRs and OP emissions, suggest the need for further studies on the secondary processing of EPFRs and OP during the lockdown period in Xi’an. .The COVID-19 lockdown had a significant impact on both social and economic aspects. The city lockdown, however, had a positive impact on the environment and improved air quality, however, no significant health benefits were observed in Xi’an, China.

To assess the influence of diastolic dysfunction on the evolution of pulmonary hypertension in neonates with Down Syndrome over the early newborn period.

This was a prospective observational cohort study. Echocardiography was performed three times over the first week of life in both Down syndrome and control cohorts. Measurements of pulmonary arterial pressure in addition to left ventricular (LV) and right ventricular systolic and diastolic function were collected.

Seventy babies with Down syndrome and 60 control infants were enrolled. Forty-eight of the infants with Down syndrome (69%) were born with congenital heart disease (CHD). Echocardiography surrogates of pulmonary hypertension and myocardial function remained significantly impaired in the Down syndrome group in comparison with control infants (all P<.01). In the Down syndrome group, LV early diastolic strain rate was independently associated with measures of pulmonary hypertension while controlling for gestational age, cesarean delivery, and the presence of CHD (P<.01).

Intrinsic LV diastolic impairment is directly associated with higher indices of pulmonary hypertension in infants with Down syndrome and may be a contributing factor to its evolution.

Intrinsic LV diastolic impairment is directly associated with higher indices of pulmonary hypertension in infants with Down syndrome and may be a contributing factor to its evolution.

To optimize the permethrin-based therapies for scabies infestations in infants and young children, the efficacies of 3 different regimens were evaluated.

The retrospective analysis encompassed 85 infants and children aged <4years with scabies. The children had received either topical permethrin 5% on the entire body on days 1/8, on days 1/8/15, on days 1/8/15 plus interim applications restricted to hands and feet on days 2/3/4//9/10/11, or alternative treatments.

The intensified regimen, consisting of full-body permethrin applied on days 1/8/15 and hands/feet on days 2/3/4//9/10/11, resulted in cure of scabies in 73.5% of the cases. The cure rates were significantly greater compared with full-body permethrin given on days 1/8, which led to eradication in 44%, and were greater compared with the clearance in children who had received full-body permethrin on days 1/8/15 (53.8%) or alternative treatments (60%). For patients in whom permethrin had previously been applied, the intensified regimen resulted in eradication of scabies in 71.4% of the cases, compared with 30% and 55.6% after full-body permethrin on days 1/8 and 1/8/15, respectively.

The intensified regimen of full-body permethrin plus interim applications on hands/feet, which aims at reducing the number of mites present on the frequently heavily infested palmoplantar sites in addition to the standard entire body application, appears efficacious in curing scabies in young children.

The intensified regimen of full-body permethrin plus interim applications on hands/feet, which aims at reducing the number of mites present on the frequently heavily infested palmoplantar sites in addition to the standard entire body application, appears efficacious in curing scabies in young children.

Pancreatic cancer has the highest prevalence of cancer-associated cachexia among all cancers. ZIP4 promotes pancreatic cancer progression by regulating oncogenic miR-373, and perturbation of circular RNAs (circRNAs)is associated with cancer aggressiveness. This study aimed to identify circRNAs involved in ZIP4/miR-373-driven cancer growth and cachexia and decipher the underlying mechanism.

Differentially expressed circRNAs and potential targets of microRNA were identified through in silico analysis. The RNA interactions were determined by means of biotinylated microRNA pulldown, RNA immunoprecipitation, and luciferase reporter assays. The function of circRNA in ZIP4-miR-373 signaling axis were examined in human pancreatic cancer cells, 3-dimensional spheroids and organoids, mouse models, and clinical specimens. Mouse skeletal muscles were analyzed by means of histology.

We identified circANAPC7 as a sponge for miR-373, which inhibited tumor growth and muscle wasting invitro and invivo. Mechanistic studidown-regulation to suppress tumor growth and muscle wasting in pancreatic cancer.Eight undescribed isosteroidal alkaloids cirrhosinones A-H (1-8), along with six known isosteroidal alkaloids (9-14), were isolated from the bulbs of Fritillaria cirrhosa D. Don. Their structures were determined by HRESIMS and 2D NMR analysis, and their absolute configurations were established by X-ray analysis. Compounds 1-8 possessed a typical cevanine-type alkaloid skeleton with a hydroxyl group rarely substituted at C-24 and compounds 4-8 possessed rare 7α or 7β-hydroxyl groups. This was the first report of both C-7 and C-24 hydroxyl groups substituted cevanine-type alkaloids. In addition, an approach for distinguishing D/E cis and trans conformations of cevanine-type alkaloids by 1H NMR data was developed. Moreover, the correlations between the relative configurations of 3-OH, 7-OH, 22-C, 24-OH, and 25-Me and the 1H NMR and 13C NMR data were also summarized. Compounds 1-9 exhibited moderate NO inhibitory activities in LPS-stimulated BV-2 cells at the concentration of 40 μM. The acetylcholinesterase inhibitory activities of compounds 1-7 and 9-10 were also evaluated and none of them showed acetylcholinesterase inhibitory activities at the concentrations of 20-80 μM.Low power density and poor anode performance seriously limit the potential of practical application of microbial fuel cell (MFC). Utilizing solar energy by developing photoanode is one of the effective pathways to improve the performance of MFC. Here solar energy harvesting was integrated into MFC to achieved the comprehensive utilization of multiple energy sources. A hybrid MFC photoanode (α-FeOOH-NWs/PANI anode) was constructed by loading polyaniline (PANI) and α-FeOOH nanowires (α-FeOOH-NWs) on carbon paper through electro-polymerization synthesis method. Compared with clean carbon paper, nanowires and PANI increased the surface roughness of the electrode, which facilitated the biofilm formation. The electrochemical and photoelectric analysis demonstrated that PANI introduced new electroactive groups and reduced the charge transfer resistance, exhibiting excellent electrochemical and photoelectric activites. The MFC with the α-FeOOH-NWs/PANI photoanode had higher voltage output and power density under light illumination, with the power density of 1.95 W/m2 under light, which was 1.4 times higher than that without light. The hybrid α-FeOOH-NWs/PANI photoanode enhanced the separation efficiency of photogenerated electron-hole pairs, thereby improving the photoelectric response capability and generating a high photocurrent. Our research provided a new concept for the combination of solar energy harvesting and MFCs, yielding an overall enhancement of electricity eneration performance in MFC.Greece produces significant amounts of residual biomass due to its intense agricultural and agro-industrial sector. The anaerobic digestion process has been frequently considered as the best environmental and economic solution for energy recovery from different biodegradable waste such as agricultural waste, livestock manure, agro-industrial waste, as well as for their co-digestion. The aim of this study was the assessment of biochemical methane potential (BMP) of biomass feedstocks representative of Northern and Southern Greece, which are available during the fall/winter and spring/summer seasons, through the implementation of BMP assays. The raw residues evaluated in the current work included (a) crop residues (corn silage and unsuitable for human consumption watermelon), (b) agro-industrial residues (malt, tomato processing residues, orange peels and olive pomace) and (c) livestock (cattle) manure. Tests of both single substrates and various mixtures were conducted for the evaluation of their methane yields. The results of the mono-substrates are in accordance with other studies in the literature, with watermelon presenting the highest methane potential (421.0 ± 3.4 ml CH4/g VSadded). After the evaluation of the mixtures and mono-substrates results, the most promising mixtures seemed to be the following a) for Northern Greece, 10% corn silage-80% cattle manure-10% malt, b) for Southern Greece spring/summer season, 10% corn silage-14% cattle manure-66% watermelon-10% tomato processing residues, and c) for Southern Greece fall/winter season, 10% corn silage-57% cattle manure-23% orange peels-10% olive pomace.Plasma techniques to degrade pollutants are generally more efficient than conventional methods, but exist some problems such as high energy consumption, incomplete degradation of pollutants, and secondary pollution caused by highly toxic intermediates. GSK126 In this study, the dielectric barrier discharge plasma (DBDP) combined with the Ti-based metal organic frameworks (MOFs) catalysts (P25/NH2-MIL-125(Ti)) was used to degrade fluorene in the soil. The synergistic treatment technique used in soil remediation can realize a green and promising treatment efficiency with relatively low energy consumption. Compared with DBDP system alone, the synergetic treatment system of DBDP and P25/NH2-MIL-125(Ti) considerably increased the degradation efficiency of fluorene in the soil to above 90% at 10 min, even with a relatively low discharge voltage (5 kV). The synergistic treatment system achieved 88.8% of fluorene mineralization at 60 min. Optical emission spectroscopy and electron paramagnetic resonance spectroscopy both showed that •OH and •O2- played an important role in the synergetic treatment system.