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The feasibility of the prediction engine as a clinical tool, the SafeHeart Platform, is assessed during the feasibility study.

Development study recruitment commenced in 2021. The feasibility study starts in 2022.

SafeHeart is the first study to prospectively collect a multimodal data set to construct a personalized prediction…[Read more]

uding sepsis, subpopulations of IBD patients, especially those undergoing strong immunosuppression might benefit from additional urolithiasis screening.

Data on the accuracy of the diagnosis of hepatopulmonary syndrome (HPS) in cirrhosis is limited. We evaluated the clinical characteristics of patients with International Classification of…[Read more]

Spatial transcriptomics is an emerging technology widely applied to the analyses of tissue architecture and corresponding biological functions. Substantial computational methods have been developed for analyzing spatial transcriptomics data. These methods generate embeddings from gene expression and spatial locations for spot clustering or tissue…[Read more]

The probability of recurring strokes in patients with atrial fibrillation is high. Within 1.8 years, 6.6% of the patients suffered a new stroke. While effective secondary prevention options exist, low adherence challenges effective medical treatment. The aim of our study was to examine the risk understanding of acute stroke patients and to find…[Read more]

Tumor-derived protein tissue inhibitor of metalloproteinases-1 (TIMP1) correlates with poor prognosis in many cancers, including highly lethal pancreatic ductal adenocarcinoma (PDAC). The noncanonical signaling activity of TIMP1 is emerging as one basis for its contribution to cancer progression. However, TIMP1-triggered progression-related…[Read more]

Remain Cozy and Cozy: The Ultimate Guide to Selecting the Perfect Furnace for Your Home

At Keep Warm and Relaxing, we recognize the importance of having a dependable heater in your house. As the temperature levels decrease and wintertime sets in, it ends up being vital to have a source of heat that keeps you and your household comfy. With many…[Read more]

The increasing volume of biomedical data in chemistry and life sciences requires development of new methods and approaches for their analysis. Artificial Intelligence and machine learning, especially neural networks, are increasingly used in the chemical industry, in particular with respect to Big Data. This editorial highlights the main results…[Read more]

High expression of integral membrane protein 2A (ITM2A) was reported to be associated with favorable prognosis in several solid tumors including breast cancer. This study aimed to investigate the role of ITM2A in breast cancer, especially in respect to tumor microenvironment.

ITM2A expression was evaluated based on qRT-PCR results on…[Read more]

This study identified the relationship between feeling of entrapment and motivation for change among hospitalized alcoholic patients and examined the double mediating effect model of social isolation and emotional support on this relationship. The study participants were 101 male and female alcoholic patients hospitalized at C hospital, which…[Read more]

They give rise to improved binding modes of H2 in the active site of MoCu CO dehydrogenase. Implications of the resulting outcomes for a better understanding of hydrogen oxidation catalysis mechanisms are proposed and discussed.A novel strategy is proposed based on the efficient energy transfer from Tb3+ to Pr3+ for the sensitive and selective…[Read more]

Women who reported a greater decline during pregnancy showed significantly higher depression and anxiety scores. In stratified analyses, only baseline mental health scores proved to be variables with stronger impact on postnatal depression and anxiety outcomes. CONCLUSION General physical activity and maternal mental health significantly influence…[Read more]