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Current research examined the differential effects of pills’ shape (angular vs. curvy) on the perceived efficacy of the medicine, evoked bodily sensations and emotions. read more We investigated these effects by using different types of angular vs. curved stimuli abstract drawn shapes (Study 1), 3D-printed mockup pills (Study 2) and photographs of…[Read more]

Among protein oxidative damages, di-tyrosine bridges formation has been evidenced in many neuropathological diseases. Combining oxidative radical production by gamma radiolysis with very performant chromatographic separation coupled to mass spectrometry detection, we brought into light new insights of tyrosine dimerization. Hydroxyl and azide…[Read more]

We propose a novel single-plane phase retrieval method to realize high-quality sample reconstruction for lensfree on-chip microscopy. In our method, complex wavefield reconstruction is modeled as a quadratic minimization problem, where total variation and joint denoising regularization are designed to keep a balance of artifact removal and…[Read more]

1%). Flattening of the retina and closure of all retinal breaks was achieved in all eyes after a single surgery. Late recurrence of retinal detachment occurred in two eyes (3.9%) due to proliferative vitreoretinopathy (PVR). No complicated cataract or iatrogenic retinal breaks were detected in all eyes.

DFCE technique could be effectively…[Read more]

Epiphytes on Posidonia oceanica play a crucial role for determination of the ecological status of marine environment in time and space besides the seagrasses alone. The study was aimed to estimate the spatiotemporal ecological status linked to variation in biometry of an epiphytic micro-calcareous red alga, Hydrolithon boreale, found on leaves of…[Read more]

It is concluded that the spatial spread of the landfill gas in the gas distribution layer is predominantly affected by texture and compaction of the overlying methane oxidation layer. In terms of methane oxidation system design, the choice of material and construction method have more impact on gas permeability than seasonal changes in soil…[Read more]

Reactivation of fetal haemoglobin (HbF) expression is an effective way to treat β-thalassaemia and sickle cell anaemia. In the present study, we identified a novel GATA zinc finger domain-containing protein 2A (GATAD2A) mutation, which contributed to the elevation of HbF and ameliorated clinical severity in a patient with β-thalassaemia, by t…[Read more]

Despite clear technical superiority of genome sequencing (GS) over other diagnostic methods such as exome sequencing (ES), few studies are available regarding the advantages of its clinical application. We analyzed 1007 consecutive index cases for whom GS was performed in a diagnostic setting over a 2-year period. We reported pathogenic and likely…[Read more]

This paper describes a novel surgical technique for successful repair of intractable corneoscleral necrosis caused by severe ocular burns. In this prospective case series, nineteen eyes of fifteen consecutive patients with sectional scleral necrosis and persistent corneal epithelial defects were treated with tenonplasty and amniotic membrane…[Read more]

Thus, backbone circularization is an excellent method for enhancing the colloidal and the conformational stability of protein with minimal sequence changes. It is therefore expected to be effective in extending the storage stability of protein therapeutics, enhancing their biological stability.Diltiazem (DIL) is a calcium channel blocker…[Read more]

The potential impact of direct-acting antivirals (DAAs) in patients with Barcelona Clinic Liver Cancer (BCLC)-B/C stage hepatocellular carcinoma (HCC) is understudied. Patients with HCC have been systematically excluded from randomised controlled trials evaluating the effectiveness of DAAs. Thus, the benefits of DAAs in patients with HCC are less…[Read more]