Activity

Altogether, PNCE has two collaborative steps including the inhibition of innate immune responses accompanied by the decrease of fibroblast populations in IPF lungs, achieving a stronger and excellent anti-fibrotic efficacy both in vitro and in vivo. This endogenous cell-based engineered liposomal nanoplatform not only allows therapeutic drugs to take effect selectively in vivo, but also provides an alternative strategy for an enhanced curative effect by modulating innate immune responses in IPF therapy.This communication reported a hypoxia-responsive fluorescent probe based on the in situ concept, which combines a water-soluble azobenzene containing copolymer with a carbamate linkage and an anionic water-soluble aggregation-induced emission fluorogen (AIEgen) tetraphenylethene (TPE). The water-soluble copolymer can be transformed into a protonated primary amine containing polymer by the reduction of the azo bond and through a 1,6-self elimination cascade reaction under hypoxic conditions. The transition of anionic TPE from the molecular dispersed state to the aggregation state induced by self-assembly with the cationic polymer would lead to an obvious increase in fluorescence according to the AIE characteristics.A silver-catalyzed efficient and direct C-H carbamoylation of quinolines with oxamic acids to access carbamoylated quinolines has been developed through oxidative decarboxylation reaction. The reaction proceeds smoothly over a broad range of substrates with excellent functional group tolerance and excellent yields under mild conditions.This work designs a PN-like junction structure by introducing Ag2O nanoparticles into lead-free 0.92K0.5Na0.5NbO3-0.08BiMnO3 solid solution films to investigate the role of PN-like junction effects in energy storage performances. It is shown that the energy storage performances are obviously improved with the energy density increasing to 65.1 J cm-3 from 20.1 J cm-3 and the efficiency to 62.6% from 50.7%. The enhancement is attributed to the formation of the depletion layer with high resistance derived from a PN-like junction structure at the interface between Ag2O nanoparticles and matrices. The rectification effect of the high resistance region in PN-like junction improves the insulation and breakdown strength, and the internal local field derived from the high resistance region divides the macroscopic domains, which are attributed to the enhancement of energy storage performances. This work provides an alternative strategy to improve the energy storage performances by designing a PN-like junction structure.Downsizing microswimmers to the nanoscale, and using light as an externally controlled fuel, are two important goals within the field of active matter. Here we demonstrate using all-atom molecular dynamics simulations that solvation relaxation, the solvent dynamics induced after visible light electronic excitation of a fluorophore, can be used to propel nanoparticles immersed in polar solvents. GSK-3 beta phosphorylation We show that fullerenes functionalized with fluorophore molecules in liquid water exhibit substantial enhanced mobility under external excitation, with a propulsion speed proportional to the power dissipated into the system. We show that the propulsion mechanism is quantitatively consistent with a molecular scale instance of self-thermophoresis. Strategies to direct the motion of functionalized fullerenes in a given direction using confined environments are also discussed.Allylic oxidation of 2-allylbenzoic acids to phthalides, instead of Wacker-type isocoumarins, was achieved with 1,2-bis(phenylsulfinyl)ethane palladium(ii) acetate (White catalyst) and oxygen in DMSO. The selective formation of 3-ethylidenephthalides or 3-vinylphthalides was controlled by the addition of acids or bases, and the reaction conditions were applied to substituted 2-allylbenzoic acids to generate corresponding phthalides selectively. Mechanistic studies, including the corresponding reaction of (E)-2-(1-propenyl)benzoic acid to 3-methylisocoumarin, isomerization reaction of 3-vinylphthalide to 3-ethylidenephthalide, and the kinetic isotope effect using 2-(1,1-d2-allyl)benzoic acid, revealed the competition between Wacker-type oxidation and allylic C-H cleavage, which is the key step to generating phthalides. A natural product, 3-ethyl-6-hydroxyphthalide, was prepared by this method.Finding new organic materials to address several issues (e.g. capacity, stability, and cycle life) in organic potassium-ion batteries (OPIBs) is very important and highly desirable. Here, to directly investigate the redox reaction of organic pyridine dicarboxylate in OPIBs and to avoid the interference from the redox-active metal ions, a non-redox-metal potassium metal-organic framework (K-MOF), [C7H3KNO4]n, based on pyridine-2,6-dicarboxylic acid (H2PDA), has been successfully synthesized and applied as a promising organic anode for long-cycle life PIBs. The crystal structure of [C7H3KNO4]n was confirmed by single-crystal X-ray diffraction analysis and FT-IR spectra. Moreover, the potassium-storage mechanism of organic pyridine dicarboxylate ligand was revealed by ex situ FT-IR/XRD characterization and theoretical calculations. The as-synthesized K-MOF resulted in a unique and reversible three-step redox reaction, exhibited superior electrochemical performance with the aid of N-K/O-K coordination bonds, and showed a high average specific capacity of 115 mA h g-1 at 100 mA g-1 for 300 cycles with the capacity retention of 92%.Silicon (Si) is an attractive photoanode material for photoelectrochemical (PEC) water splitting. However, Si photoanode towards the oxygen evolution reaction (OER) is highly challenged due to its poor stability and catalytic inactivity. The integration of highly active electrocatalysts with Si photoanodes has been considered to be an effective strategy to improve their OER performance by accelerating the reaction kinetics and inhibiting Si photocorrosion. In this work, ultra-small NiFe nanoparticles are deposited onto the n-Si/Ni/NiOOH surface to improve the activity and stability of Si photoanodes by engineering the electrocatalyst and Si interface. Ultra-small NiFe nanoparticles can introduce oxygen vacancies via modulating the local electronic structure of Ni hosts in NiOOH electrocatalysts for fast charge separation and transfer. Besides, NiFe nanoparticles can also serve as a co-catalyst exposing more active sites and as a protection layer preventing Si photocorrosion. The as-prepared n-Si/Ni/NiOOH/NiFe photoanode exhibits excellent OER activity with an onset potential of 1.