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4%) patients during a mean time of FUP 19±23 months. One-year risk of RIS was 3.4% (95%CI 1.4-6.8%). Patients with RIS were older (47.4 vs. 41.1 years, p=0.007) and more often obese (71.4 vs. 19.7%, p=0.006), and did not differ in any of other analyzed parameters and VRF. Multivariate logistic regression analysis showed obesity (OR 9.527; 95%CI 1.777-51.1) and the previous use of antiplatelets (OR 15.68; 95%CI 2.430-101.2) as predictors of recurrent IS.

Despite a higher presence of VRF in young CIS patients, the risk of RIS was very low. Obesity and previous use of antiplatelet therapy were found the only predictors of RIS.

Despite a higher presence of VRF in young CIS patients, the risk of RIS was very low. Obesity and previous use of antiplatelet therapy were found the only predictors of RIS.

Acute vertigo (sense of motion) can be the sole manifestation of a posterior circulation stroke, and often gets missed in the emergency department (ED). The studies for evaluation of central vertigo have focused on physical exam findings, which require expertise and may not be suitable for rapid triage by a nurse in ED or by paramedics.

This cross sectional study included retrospective chart review of patients 18 years of age and older who presented to the Adult ED with acute dizziness or vertigo during the calendar year 2017. All the patients with a diagnosis of central or peripheral vertigo were included in the final analysis. Sensitivity, specificity, Likelihood Ratio of positive result (LR (+)) and Likelihood Ratio of negative result (LR (-)) for central and peripheral vertigo were calculated for risk factors, symptoms and physical examination features. Chi-squared test and univariate logistic regression were used to evaluate statistical correlation and to calculate the prevalence odds ratio (POR).

entral vertigo in the ED.

Text mining with automatic extraction of key features is gaining increasing importance in science and particularly medicine due to the rapidly increasing number of publications.

Here we evaluate the current potential of sentiment analysis and machine learning to extract the importance of the reported results and conclusions of randomized trials on stroke.

PubMed abstracts of 200 recent reports of randomized trials were reviewed and manually classified according to the estimated importance of the studies. Importance of the papers was classified as “game changer”, “suggestive”, “maybe” “negative result”. Algorithmic sentiment analysis was subsequently used on both the “Results” and the “Conclusions” paragraphs, resulting in a numerical output for polarity and subjectivity. The result of the human assessment was then compared to polarity and subjectivity. In addition, a neural network using the Keras platform built on Tensorflow and Python was trained to map the “Results” and “Conclusions” to the dichotomirent statistical approaches to text analysis can grasp the impact of scientific medical abstracts to a certain degree. Sentiment analysis showed that mediocre results are apparently written in more enthusiastic words than clearly positive or negative results.

Ischemia-reperfusion injuries (IRIs) can aggravate the condition of some patients with acute occlusion of major intracranial artery (AOMIA) who received endovascular thrombectomy. Here, we provided data confirming the association of Repressor Element-1 Silencing Transcription factor (REST) with the long-term neuroprotective effect of the middle cerebral artery occlusion (MCAO) rats underwent Gradual Flow Restoration (GFR).

Long term neuroprotective effects of GFR intervention were evaluated on MCAO rats model after 3d and 7d reperfusion. The neurological deficit score and TTC staining were performed to evaluate the degree of brain damage in GFR and other interventions at different time. Differentially expressed genes related to cerebral ischemia reperfusion injury (CIRI) were initially screened and identified using GSE32529 microarray analysis. REST protein expression in rat brain cortex infarction was detected by Western blot analysis.

MCAO rats intervened with GFR exhibited reduced neurological deficit (P<0.05) and alleviated brain infarction volume (P<0.01). The REST gene with up-regulated expression and its downstream genes with down-regulated expression were screened by Microarray analysis. The brain cortex infarction in MCAO rats produced high levels of REST expression. The GFR intervention inhibited REST expression, and alleviated brain injury on MCAO rats.

Our results demonstrated that GFR intervention plays a long-term neuroprotective role and reduces brain edema and damage at reperfusion, possibly by inhibiting REST expression.

Our results demonstrated that GFR intervention plays a long-term neuroprotective role and reduces brain edema and damage at reperfusion, possibly by inhibiting REST expression.

Emotional disturbances, such as anxiety and depression are common after acute ischemic stroke (AIS). learn more Individual variation in emotional outcome is strongly influenced by genetic factors. One of pituitary axis, is the hypothalamic-pituitary-thyroid axis, a critical regulator of post-stroke recovery, suggesting that allelic variants in thyroid hormone (TH) signaling regulation can influence stroke outcome.

To determine associations between AIS emotional outcome and allelic variants of the TH metabolizing enzymes 1-3 type deiodinase (DIO1-3) and the membrane transporting organic anion polypeptide 1C1 (OATP1C1).

Eligible AIS patients from Lithuania (n=168) were genotyped for ten DIO1-3 and OATP1C1 single nucleotide polymorphisms (SNP) DIO1 rs12095080-A/G, rs11206244-C/T, and rs2235544-A/C; DIO2 rs225014-T/C and rs225015-G/A; DIO3 rs945006-T/G; OATP1C1 rs974453-G/A, rs10444412-T/C, rs10770704-C/T, and rs1515777-A/G. Emotional outcome was evaluated using the Hospital Anxiety and Depression Scale at discharge from the neurology department after experienced index AIS.

After adjustment for potential confounders, the major allelic (wild-type) DIO1-rs12095080 genotype (AA) was associated with higher odds ratio of anxiety symptoms (OR = 5.16; 95% CI 1.04-25.58; p = 0.045), conversely, DIO1-rs11206244 wild-type genotype (CC) and wild-type OATP1C1-rs1515777 allele containing the genotypes (AA + AG) were associated with lower odds ratio of symptoms of anxiety (OR = 0.37; 95% CI 0.14-0.96; p = 0.041 and OR = 0.30; 95% CI 0.12-0.76; p = 0.011, respectively). Wild-type OATP1C1-rs974453 genotype (GG) was associated with higher odds ratio of symptoms of depression (OR = 2.73; 95% CI 1.04-7.12; p = 0.041).

Allelic variants in thyroid axis genes may predict emotional outcomes of AIS.

Allelic variants in thyroid axis genes may predict emotional outcomes of AIS.