Activity

A 2D coordination polymer, [Fe(L)2(NCSe)2]·6MeOH·14H2O n (1; L = 2,5-dipyridylethynylene-3,4-ethylenedioxythiophene), has been synthesized based on a redox active luminescence ligand. 1 possesses a 2D [4 × 4] square-grid network where the iron(II) center is in a FeN6 octahedral coordination environment. 1 displays reversible thermoinduced high-spin (HS; S = 2) to diamagnetic low-spin (LS; S = 0) ON/OFF spin-state switching with a T1/2 value of 150 K. Interestingly, optical reflectivity and photomagnetic studies at 10 K under light irradiation revealed an efficient conversion to a photoinduced metastable HS excited state from a LS ground state. Remarkably, the photoexcited HS state can be reversibly switched ON and OFF by using 625 and 850 nm light-emitting-diode lights. Intriguingly, the thermal dependence of the luminescence intensity of the maximum emission at 524 nm for 1 shows a minimum at around the spin-crossover (SCO) temperature, indicating a cooperative nature between the SCO and luminescence properties. Theoretical calculations confirmed the above findings.Anaerobic membrane bioreactors (AnMBRs) can significantly reduce the release of antibiotic resistance elements to the environment. The purpose of this study was to elucidate the role of membrane fouling layers (biofilms) in mitigating the release of intracellular and extracellular antibiotic resistance genes (iARGs and eARGs) from an AnMBR. The AnMBR was equipped with three membrane modules, each exhibiting a different level of fouling. Nab-Paclitaxel Results showed that the absolute abundance of ARGs decreased gradually in the suspended biomass during operation of the AnMBR. Normalized abundances of targeted ARGs and intI1 were found to be significantly higher in the fouling layers compared to the suspended biomass, implying adsorption or an increased potential for horizontal gene transfer of ARGs in the biofilm. Effluent ARG data revealed that the highly fouled (HF) membrane significantly reduced the absolute abundance of eARGs. However, the HF membrane effluent concomitantly had the highest absolute abundance of iARGs. Nevertheless, total ARG abundance (sum of iARG and eARG) in the effluent of the AnMBR was not impacted by the extent of fouling. These results suggest a need for a combination of different treatment technologies to effectively prevent antibiotic resistance proliferation associated with these two ARG fractions.The first asymmetric total syntheses of the real isolation product (2S,5R,8R)-greensporone F and (2S,5R,8R)-dechlorogreensporone F, 14-membered resorcylic acid lactones with a cis-2,5-disubstituted tetrahydrofuran ring system, was accomplished. The synthesis features a late-stage Lewis acid-catalyzed stereoselective intramolecular oxa-Michael reaction, E-selective ring-closing metathesis, De Brabander’s esterification, and Jacobsen’s hydrolytic kinetic resolution as the key steps. Synthesis of both real isolation and erroneously proposed structure necessitated the revision of the absolute configuration of greensporone F and dechlorogreensporone F. The erroneous representation of (2S,5S,8S)-configuration in greensporone F and dechlorogreensporone F was assigned to be (2S,5R,8R) by comparison with the NMR data and specific rotation of the synthetic compounds with that of the reported data.Null aggregates are an elusive, emergent class of molecular assembly categorized as spectroscopically uncoupled molecules. Orthogonally stacked chromophoric arrays are considered as a highlighted architecture for null aggregates. Herein, we unveil the null exciton character in a series of crystalline Greek cross (+)-assembly of 6,13-bisaryl-substituted pentacene derivatives. Quantum chemical computations suggest that the synergistic perpendicular orientation and significant interchromophoric separations realize negligible long-range Coulombic and short-range charge-transfer-mediated couplings in the null aggregate. The Greek cross (+)-orientation of pentacene dimers exhibits a selectively higher electron-transfer coupling with near-zero hole-transfer coupling and thereby contributes to the lowering of charge-transfer-mediated coupling even at shorter interchromophoric distances. Additional investigations on the nature of excitonic states of pentacene dimers proved that any deviation from a 90° cross-stacked oomophoric systems can offer an extensive ground for the engineering of functional materials with advanced optoelectronic properties.Triethylamine is extremely harmful to human health, and chronic inhalation can lead to respiratory and hematological diseases and eye lesions. Hence, it is essential to develop a triethylamine gas-sensing technology with high response, selectivity, and stability for use in healthcare and environmental monitoring. In this work, a simple and low-cost sensor based on the Pt- and Ce-modified In2O3 hollow structure to selectively detect triethylamine is developed. The experimental results reveal that the sensor based on 1% Pt/Ce12In exhibits excellent triethylamine-sensing performance, including its insusceptibility to water, reduced operating temperature, enhanced response, and superior long-term stability. This work suggests that the enhancement of sensing performance toward triethylamine can be attributed to the high relative contents of OV and OC, large specific surface area, catalytic effect, the electronic sensitization of Pt, and the reversible redox cycle properties of Ce. This sensor represents a unique and highly sensitive means to detect triethylamine, which shows great promise for potential applications in food safety inspection and environmental monitoring.Skin (contact) allergy, the most predominant form of immunotoxicity in humans, is caused by small electrophilic compounds (haptens) that modify endogenous proteins. Approximately 20% of the general population in the Western world is affected by contact allergy. Although the importance of the hapten-protein conjugates is well established in the initiation of the immunological reaction, not much progress has been made regarding identification of these conjugates in vivo or exploration of their potential as diagnostic tools. In this study, the human serum albumin (HSA) and human hemoglobin (Hb) adductome for three representative contact allergens with different chemical properties, 1-chloro-2,4-dinitrobenzene (DNCB), 1,2-epoxy-3-phenoxypropane (PGE), and 2-bromo-2-(bromomethyl)glutaronitrile (MDBGN), were studied. Plasma and red blood cell lysate were used as a source for HSA and Hb, respectively. The Direct Peptide Reactivity Assay was used to investigate adduct formation of MDBGN with nucleophilic moieties and revealed that MDGBN is converted to 2-methylenepentanedinitrile in the presence of sulfhydryl groups prior to adduct formation.