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Planning for health care services provision depends on the morbidity profile, health-seeking behavior (HSB), and its predictors. Thus, this study aimed to identify the level of self-reported morbidity, HSB and its predictors.

A community-based cross-sectional study was conducted among the geriatric (≥60 years) population in West Shoa Zone. A multi-stage systematic sampling technique was employed to select the study participants. After testing for collinearity, variables with p-value <0.25 on binary logistic regression were entered into backward multivariate logistic regression analysis with statistical significance at p-value <0.05.

With a response rate of 98%, 779 study participants were recruited. The median (IQR) age of the respondents was 70 (70-78) years. Five hundred eighty-four (3/4) of the study participants reported that they experienced morbidity at least once in the year before interview. Of 584 study participants, 53.9% had poor HSB. Living in village (p-value = 0.034), being housewifer, modifiable predictors of HSB needs to be improved.

There was a high prevalence of self-reported morbidity and poor HSB. There should be an effort to improve the HSB and CBHI utilization of the geriatric population by all stakeholders. Moreover, modifiable predictors of HSB needs to be improved.

Diallyl sulfide (DAS), one of the organo-sulfur secondary metabolites in garlic, has been shown to inhibit the proliferation of cancer cells. The present study aimed to evaluate the mechanism of DAS in the prevention of benzo[a]pyrene (BaP)-induced lung cancer in a murine model.

The mice were exposed to 50 mg/kg of BaP twice a week for 4 weeks in order to induce lung carcinoma. Pretreatment of mice with DAS (100 mg/kg) was started 2 weeks before BaP exposure and further continued for 21 weeks. The effect of DAS and BaP was evaluated by studying various parameters in the serum and tissues of the treated or untreated BaP-exposed mice.

The histopathological findings demonstrated that DAS prevented the progression of malignant lung cancer and metastasis in the liver. this website A significant drop was observed in BaP-induced tumor marker enzymes (ADA, AHH, γ-GT, LDH) in the serum of the mice treated with DAS. Moreover, DAS treatment resulted in the recovery of antioxidant enzymes, SOD and CAT, in BaP-exposed mice. The induction of apoptosis and the destruction of cellular ROS were detected in cancer cells from the mice pre-treated with DAS. The immunohistochemical analysis revealed the up-regulation of fatty acid synthase (FASN) in the lungs and liver tissues of BaP-exposed mice and the treatment with DAS inhibited FASN expression.

The findings of the present study indicated that DAS-induced apoptosis is strongly associated with the downregulation of FASN in tumor tissues. To the best of our knowledge, this is the first study that describes the role of FASN in BaP-induced lung carcinogenesis.

The findings of the present study indicated that DAS-induced apoptosis is strongly associated with the downregulation of FASN in tumor tissues. To the best of our knowledge, this is the first study that describes the role of FASN in BaP-induced lung carcinogenesis.

Ageing is an inevitable physiology process of humans, and skin biophysical parameters change owing to genetic and environmental factors in different ethnic populations.

To gain comprehensive data on the skin biophysical parameters of different anatomical regions and to explore the change trend of the skin characteristics associated with age for the indicated regions by generalized additive model.

We measured various skin biophysical parameters on forehead, cheek, chin and inner forearm of 178 Chinese women aged between 20 and 64 years living in Beijing. These parameters comprised skin hydration, transepidermal water loss (TEWL), sebum content, erythema index (EI), melanin index (MI), L*a*b* values, individual typology angle (ITA) and pH, which were quantified by non-invasive instruments.

Comparing the skin parameters among the four test areas, we observed that the hydration, TEWL, EI and a* values were significantly higher for the face than for the forearm, but the L* and ITA values were just the opposite. The cheek was the lightest and brightest region with lowest sebum content, while the chin was much darker and the forehead was yellowish. Considering the change of the skin parameters with age, TEWL, sebum content and melanin and erythema indices had a linear relationship with age, whereas skin hydration, L, a, b, ITA and pH values exhibited a non-monotonic relationship. The turning points of these curves appeared almost at the thirties, showing the lightest and evenest skin color and more hydration, with lower pH values.

This study indicates that the skin biophysical characteristics of Chinese women were significantly affected by age and body regions.

This study indicates that the skin biophysical characteristics of Chinese women were significantly affected by age and body regions.

The objective of this study was to forecast the prevalence rates and the populations of overweight and obese in Chinese adults for 2030.

Nine waves of ChinaHealth and Nutrition Survey (CHNS) data from 1991 to 2015 were used. A polynomial regression model was fitted to obtain the average BMI change trajectory of the population born in different years according to different sexes and residence areas (urban and rural). The model fitted to CHNS 2015 survey data was used to forecast the distribution of BMI and the prevalence rates of overweight and obesity in 15 years. The United Nations population forecast was then used to predict the proportions of overweight obese adults in all age groups in China in 2030.

The prevalence rates of overweight and obesity were projected to increase in both sexes and all geographic areas in future. By 2030, urban males will have the highest prevalence of overweight, 50.7% (95% CI 47.5%, 53.9%). Except urban males, the prevalence of overweight and obesity in rural areas will eve a huge impact on the health of the Chinese population over the next 15 years.

To investigate the prevalence of variants within selected maturity-onset diabetes of the young (MODY)-genes among Algerian patients initially diagnosed with type 1 diabetes (T1D) or type 2 diabetes (T2D), yet presenting with a MODY-like phenotype.

Eight unrelated patients with early-onset diabetes (before 30 years) and six relatives with diabetes were examined by targeted re-sequencing for variants in genes known to be involved in MODY (

). Clinical data for probands were retrieved from hospital records.

A total of 12 variants were identified, of which three were classified as pathogenic and one as a variant of uncertain clinical significance (VUS). Two of the pathogenic variants were found in

(p.Gly261Arg and p.Met210Lys, respectively) in one proband each and the remaining pathogenic variant was found in

(p.Gly76Cys) in a proband also carrying the VUS in

(p.Thr156Met).

Variants in known MODY-genes can be the cause of early-onset diabetes in Algerians diagnosed with T1D or T2D among patients presenting with a MODY-like phenotype; thus, genetic screening should be considered.