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We estimate that there is a 97% probability that the effect of MapTrek is at least 1,000 additional steps per day throughout the course of the 6-month intervention and that MapTrek participants would have walked an additional 81 miles, on average, before the effect ended. Our MapTrek intervention led to significant extra walking by the MapTrek participants.The ongoing COVOD-19(SARS-CoV-2) outbreak has had a devastating impact on the economy, education and businesses. In this paper, the behavior of an epidemic is simulated on different contact networks. Herein, it is assumed that the infection may be transmitted at each contact from an infected person to a susceptible individual with a given probability. The probability of transmitting the disease may change due to the individuals’ social behavior or interventions prescribed by the authorities. We utilized simulation on the contact networks to demonstrate how seesaw scenarios of lockdown can curb infection and level the pandemic without maximum pressure on the poor societies. 6-Diazo-5-oxo-L-norleucine Soft scenarios consist of closing businesses 2, 3, and 4 days in between with four levels of lockdown respected by 25%, 50%, 75%, and 100% of the population. The findings reveal that the outbreak can be flattened under softer alternatives instead of a doomsday scenario of complete lockdown. More specifically, it is turned out that proposed soft lockdown strategies can flatten up to 120% of the pandemic course. It is also revealed that transmission probability has a crucial role in the course of the infection, growth rate of the infection, and the number of infected individuals.Kidney cancer, with 4% of all malignancies, is one of the most common malignancies occurring among in adults. In Saudi Arabia, kidney cancer comprises 2.3% of all cancers, and its incidence has increased by 33%. Partial nephrectomy (PN) is considered as the gold standard for T1 renal masses. In this retrospective study, we did a chart review for all patients who underwent PNs between April 2013 and February 2019. Data comprised presentation, tumor size, type of procedure (open vs. laparoscopic vs. robotic), and intra- and post-operative complications. Chi-square, ANOVA, and cross-tabulation were done using SPSS software. P > 0.05 was considered significant. Approval was obtained from the institutional review board of King Abdullah International Medical Research Center. In all, 69 patients were identified 26 (37.7%) males and 43 (62.3%) females, with mean age = 54.53 ± 13.21 years; mean body mass index = 32.36 ± 7.03, and mean tumor size = 3.7 ± 1.72 cm. In terms of presentation, most patients (50, 72.4%) presented incidentally as opposed to symptomatic presentation. Of these patients, 18 (26.1%) underwent open partial nephrectomy (OPN), 29 (42%) laparoscopic partial nephrectomy (LPN), and 22 (31.9%) robotic partial nephrectomy (RPN). On comparing minimally invasive surgery (MIS) PN with OPN, we found that OPN had more blood loss and a longer hospital stay but a shorter operating room (OR) time. Results of PN irrespective of the procedure type, whether it was OPN, LPN, or RPN, were similar if performed by experienced surgeons. However, open procedures involved a higher blood loss, more operative time, and longer hospital stay when compared with minimally invasive techniques.In this study, we aimed to evaluate the impact of surgical wait time (SWT) on outcomes of patients with renal cell carcinoma (RCC), and to investigate risk factors associated with prolonged SWT. Using the National Cancer Database, we retrospectively reviewed the records of patients with pT3 RCC treated with radical or partial nephrectomy between 2004 and 2014. The cohort was divided based on SWT. The primary outcome was 5-year overall survival (OS). Logistic regression analysis was used to investigate the risk factors associated with delayed surgery. Cox proportional hazards models were fitted to assess relations between SWT and 5-year OS after adjusting for confounding factors. A total of 22,653 patients were included in the analysis. Patients with SWT > 10 weeks had higher occurrence of upstaging. Using logistic regression, we found that female patients, African-American or Spanish origin patients, treatment in academic or integrated network cancer center, lack of insurance, median household income of 10 weeks is associated with decreased 5-year OS.Renal angiomyolipoma is a rare cause of renal tumor in children. Most are associated with tuberous sclerosis, and the classic type is observed more commonly. Epithelioid angiomyolipoma is even rarer with only limited case reports and series published in literature, most of which are of adult patients. We describe a 12-year-old boy, a diagnosed patient of tuberous sclerosis, who presented with pain in the left flank. On evaluation, it was found to have a left renal mass with the clinical picture suggestive of renal cell carcinoma. Partial nephrectomy was performed and histopathology revealed epithelioid angiomyolipoma. The child was asymptomatic at follow-up after 3 months. Only a few such cases in children are found in literature, which are discussed alongside. Differential diagnosis of this rare tumor must be kept in mind in a renal tumor as surgery is generally curative in this possibly malignant tumor. Metastasis confers a poor prognosis. Chemotherapy is generally not effective, although various regimens have been tried. Tumor recurrence must be kept in mind and a follow-up after apparent complete remission is of paramount importance.Chemical laboratories have existed since the late sixteenth century. Two basic designs have dominated this history a furnace-centred laboratory based on earlier alchemical workshops up to around 1820 and then a design based on the use of the Bunsen burner with benches and bottle racks since the 1850s (the “classical” laboratory). New designs with a focus on health and safety began to appear at the end of the twentieth century. There has been an important interaction between the design of the laboratory and chemical practice, including how chemistry was taught. In particular, the introduction of running water and piped gas was crucial to the creation of the “classical” laboratory in the 1860s. One aspect of the classical laboratory which has disappeared is the chemical museum. This article considers university, industrial and school laboratories, and also the social organisation of the laboratory. Finally, the article considers the future of chemical laboratories and chemical practice.