Activity

5Cd0.5S to react with the sacrificial reagents. Moreover, the composite presents improved stability without notable activity decay after several cycled tests.Er3+/Yb3+ co-doped Bi5O7I uniform porous microsphere photocatalysts were synthesized by a two-step chemical method, which possesses excellent photocatalytic performance and upconversion luminescence property. The photocatalytic performance of the photocatalysts was studied by degradation of bisphenol A in aqueous solution under visible light and different monochromatic light irradiation. The photocatalytic performance of Er3+/Yb3+ co-doped Bi5O7I sample is better than that of the pristine Bi5O7I and Er3+-doped Bi5O7I samples. Moreover, Er3+/Yb3+ co-doped Bi5O7I possesses photocatalytic ability with a red light monochromatic LED lamp (3 W, λ = 630 nm) and an infrared monochromatic LED lamp (100 W, λ = 940 nm) irradiation whose wavelength is longer than the absorption-limiting wavelength of pristine Bi5O7I sample. This phenomenon further verified that the upconversion property of Er3+ and Yb3+ causes the improved photocatalytic efficiency of Er3+/Yb3+ co-doped Bi5O7I sample.Photodynamic therapy (PDT) is a promising and minimally invasive modality for the treatment of cancers. The use of a self-illuminating system as a light source provides an intriguing solution to the light penetration issues of conventional PDT, which have gained considerable research interest in the past few years. This mini review aimed to present an overview of self-illuminating PDT systems by using internal light sources (chemiluminescence, bioluminescence, and Cerenkov radiation) and to give a brief discussion on the current challenges and future perspectives.Ochratoxin A (OTA) is a mycotoxin that is widespread throughout the world. It contaminates foods such as vegetables, fruits, and rice. It harms human health and has potential carcinogenic effects. The G-quadruplex (G4) is a tetraplexed DNA structure generated from guanine-rich DNA that has found emerging use in aptamer-based sensing systems. This review outlines the status of OTA contamination and conventional detection methods for OTA. Various G4-based methods to detect OTA developed in recent years are summarized along with their advantages and disadvantages compared to existing approaches.Under the excitation of ultraviolet, X-ray, and mechanical stress, intense orange luminescence (Mn2+, 4T1 → 6A1) can be generated in Mn2+-doped SrZn2S2O crystal in orthorhombic space group of Pmn21. Herein, the multiple energy conversion in SrZn2S2OMn2+, that is, photoluminescence (PL), X-ray-induced luminescence, and mechanoluminescence, is investigated. Insight in luminescence mechanisms is gained by evaluating the Mn2+ concentration effects. Under the excitation of metal-to-ligand charge-transfer transition, the most intense PL is obtained. X-ray-induced luminescence shows similar features with PL excited by band edge UV absorption due to the same valence band to conduction band transition nature. Benefiting much from trap levels introduced by Mn2+ impurities, the quenching behavior mechanoluminescence is more like the directly excited PL from Mn2+ d-d transitions. Interestingly, this concentration preference leads to varying degrees of spectral redshift in each mode luminescence. Further, SrZn2S2OMn2+ exhibits a good linear response to the excitation power, which makes it potential candidates for applications in X-ray radiation detection and mechanical stress sensing.

The monocarboxylate transporter 8 (MCT8; SLC16A2) is a specific transporter for thyroid hormones. MCT8 deficiency, formerly known as the Allan-Herndon-Dudley syndrome, is a rare genetic disease that leads to neurological impairments and muscle weakness. Current experimental treatment options rely on thyromimetic agonists that do not depend on MCT8 for cellular uptake. Another approach comes from studies with the chemical chaperone sodium phenylbutyrate (NaPB), which was able to stabilize MCT8 mutants having protein folding defects in vitro. In addition, NaPB is known as a compound that assists with plasma membrane translocation.

The pathogenic MCT8

leads to the same severe neurological impairments found for other MCT8-deficient patients but, unexpectedly, lacks alterations in plasma 3,3′,5-triiodothyronine (T₃) levels. Here we tried to unravel the underlying mechanism of MCT8 deficiency and tested whether the pathogenic MCT8

mutant responds to NaPB treatment. Therefore, we overeng and protein degradation, but also for a mutant wrongly sorted inside a cell which is otherwise functional.

NaPB is not only suitable for the treatment of mutations leading to misfolding and protein degradation, but also for a mutant wrongly sorted inside a cell which is otherwise functional.

Resistance to thyroid hormone beta (RTHβ) is a rare disease with an autosomal dominant transmission. Diagnosis may be challenging especially in patients with hyper- or hypothyroidism.

A 31-year-old male patient with suppressed thyroid-stimulating hormone (TSH), elevated free thyroxine and free triiodothyronine, along with high thyroid receptor antibodies was diagnosed with Graves’ disease. Benzylthiouracil was started. One month later, reduced sensitivity to thyroid hormones was suspected because of persistently high thyroid hormone levels contrasting with high TSH level. Molecular analysis highlighted a 10c.1357C>T p.P453S mutation in the thyroid hormone receptor beta gene (

). RTHβ was diagnosed. Several relatives also had RTHβ (the mother, the young son, and 2 out of 3 siblings). Autoimmune hypothyroidism was present in the mother, whereas 2 out of 3 siblings had asymptomatic autoimmunity.

Both Graves’ disease and autoimmune hypothyroidism were described in patients with RTHβ. We show here for the first time that autoimmune hypo- and hyperthyroidism may coexist in kindred with RTHβ. Seven previously published cases of Graves’ disease and RTHβ were retrieved and analyzed. Treatments and thyroid hormone level targets are discussed as well as the possible link between RTHβ and autoimmune thyroid diseases.

Both Graves’ disease and autoimmune hypothyroidism were described in patients with RTHβ. We show here for the first time that autoimmune hypo- and hyperthyroidism may coexist in kindred with RTHβ. Seven previously published cases of Graves’ disease and RTHβ were retrieved and analyzed. this website Treatments and thyroid hormone level targets are discussed as well as the possible link between RTHβ and autoimmune thyroid diseases.