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gh detailed visual examination appears to be effective in identifying, previous systematic reviews have not evaluated a relevant number of studies and they did not evaluate the accuracy of the clinical examination.

We aimed to compare oral and pathogenic microorganisms in bloodstream infections (BSIs) in allogeneic hematopoietic stem cell transplantation (allo-HSCT). We also investigated the relationship between BSIs and oral mucositis to identify the ratio of BSIs caused by oral microorganisms and the pathogenic microorganisms involved.

We collected data on BSIs in 96 patients who underwent allo-HSCT in our institute between April 2009 and December 2019, including BSI pathogens isolated from blood cultures (BBSIs) and microorganisms isolated from washing the oral cavity with sterile distilled water. Oral microorganisms obtained at the onset of BSI (OBSIs) and during allo-HSCT (OSCTs) were defined as isolates collected during the week of blood culturing. Study entry was limited to samples collected up to 1month after allo-HSCT without BSI. When the BBSI and OBSI were the same, we considered the oral microorganism to have caused the BSI.

The incidence rate of BSIs was 27%, and the predominant microorganism was coagulase-negative Staphylococci. Normal bacterial flora were decreased to 15.8% in OBSIs and 25.5% in OSCTs. The distribution of microorganisms without normal bacterial flora showed significant difference between BBSIs and OSCTs (p < 0.05). Oral mucositis was found in 72.9%, and BSI caused by oral microorganisms occurred in 46.2% of BSIs in allo-HSCT patients.

The distribution of microorganisms obtained from blood in patients with BSI during allo-HSCT was found to be similar to that of microorganisms from oral cultures.

Oral microorganism monitoring may be able to predict BSI during allo-HSCT.

Oral microorganism monitoring may be able to predict BSI during allo-HSCT.

To compare the effect between intra-articular infiltration of low molecular weight (LMW-HA) and high molecular weight hyaluronic acid (HMW-HA) on the histopathological characteristics of the cartilage and disc of the temporomandibular joint (TMJ) osteoarthritis (OA) induced in rabbits.

An experimental study was conducted on 38 rabbit TMJs. The effect of different hyaluronic acids was compared at 30 and 135days. Histopathological analysis was performed. Cartilage damage was assessed with the OARSI scale.

The severity of the induced OA according to OARSI was 3.4 degrees in the mandibular condyle (MC) and 3.2 in the mandibular fossa (MF); the articular disc (AD) presented disorganization of the collagen fibers, with randomly arranged hypertrophic chondrocytes. At 30days, untreated TMJs worsened. TMJ treated with LMW-HA reduced its severity to 1.5 degrees in MC and 1.6 in MF, the AD presented histological aspects within normal limits. TMJ treated with HMW-HA presented 2.4 degrees in MC and 2.2 in MF, the AD maintained characteristics similar to the group with OA. At 135days, all groups worsened.

Exogenous HA is effective in the management of TMJ-OA induced in rabbits, showing cartilage and articular disc repair at 30days. The LMW-HA group had better effects on joint tissue than HMW-HA 30days after treatment. However, at 135days, both groups presented regression of joint tissue repair.

HA is effective in the anti-arthritic treatment of TMJ-OA induced in rabbits; LMW-HA shows better results in cartilage and articular disc repair than HMW-HA.

HA is effective in the anti-arthritic treatment of TMJ-OA induced in rabbits; LMW-HA shows better results in cartilage and articular disc repair than HMW-HA.

This study evaluated the efficacy of 5% and 10% glycolic acid solutions for the removal of calcium hydroxide medicament from artificial internal resorption cavities.

A total of 170 human maxillary premolars were selected and artificial internal resorption cavities were prepared using round burs and 37% orthophosphoric acid in the apical third of the root halves. Entire canal and resorption cavity were filled with calcium hydroxide paste. Then, the specimens were assigned to 2 control groups or ten experimental groups according to the irrigating solutions used for medicament removal with and without activation with ultrasonic energy as following 5% glycolic acid, 10% glycolic acid, 17% EDTA, and 10% citric acid and distilled water. The resorption cavities were examined under different magnifications using stereomicroscopy and scanning electron microscopy (SEM). The calcium hydroxide remnants in the resorption cavity were scored by 2 evaluators using a 4-scoring scale. The data were analyzed with Kruskal-Wal irrigating solutions, complete elimination of medicament remnants was unattainable.

This study showed the improved efficacy of ultrasonically activated 10% glycolic acid in removing the calcium hydroxide medicament from the internal resorption cavity.

This study showed the improved efficacy of ultrasonically activated 10% glycolic acid in removing the calcium hydroxide medicament from the internal resorption cavity.

Although panoramic radiographs are extensively studied for diagnosis and preoperative planning in third molar surgery, research on the predictive value of this radiographic information regarding the postoperative recovery of patients remains underexploited. This prospective cohort study aimed to assess the potential relationship between radiologic risk indicators and persistent postoperative morbidity, in 1009 patients undergoing 2825 third molar extractions in context of the M3BE study.

Two observers evaluated ten radiographic parameters vertical and horizontal eruption status, third molar orientation, surgical difficulty, nerve relation, maxillary sinus relation, presence of periapical and pericoronal radiolucencies, caries, and third or second molar resorption. Patients’ postoperative recovery was recorded 3 and 10days after surgery. Univariate logistic regression was performed to assess potential associations between radiographic risk indicators and persistent postoperative morbidity.

Deep impactionty were identified.

To assess the influence of different sealers used in root canal filling, in terms of bond strength (BS) to dentin, after restoration of weakened roots using resin composite (RC) and fiber posts.

Roots of 39 maxillary incisors were used. After root canal preparation, root dentin was flared to produce a space between fiber post and root canal walls. The root canals were randomly distributed into three groups (n = 13), according to the sealer used Endofill, AH Plus, and Acroseal. After removing the filling material to a depth of 12 mm, the flared roots were adhesively restored using RC. Posts were cemented and, after 24 h, roots were sectioned transversely producing 1-mm-thick slices. The slices from 30 roots were used for push-out test, and failure modes were noted. The remaining slices were analyzed by scanning electron microscopy (SEM).

Statistical analysis by 2-way ANOVA showed a significant difference among sealers (p = 0.001) and among root regions (p < 0.001). The BS mean of Endofill was lower and significantly different from the others. Overall, the coronal region presented higher BS mean values, followed by the middle and apical regions of the reinforced roots. see more The most frequent failure type was the adhesive failure between RC and dentin. SEM analysis showed the formation of a hybrid layer and many tags in the coronal and middle regions, while the apical region exhibited remnants of the endodontic sealers in all groups.

AH Plus and Acroseal sealer groups presented similar results, and the Endofill sealer negatively affected the BS of fiber post to restored root dentin.

Weakened dentin walls are often found in teeth undergoing endodontic treatment, so the sealer used must allow or at least not interfere the bonding between restorative materials and root dentin.

Weakened dentin walls are often found in teeth undergoing endodontic treatment, so the sealer used must allow or at least not interfere the bonding between restorative materials and root dentin.

To evaluate if the ultrasonic activation of sealer hinders the root canal retreatment.

Thirty mandibular premolars were prepared using the ProTaper Universal system (Dentsply) until the instrument F3 (0.30/0.09). The canals were distributed into 2 groups (n= 15), according to the filling technique NUact group – sealer without ultrasonic activation + gutta-percha cones and Uact group – sealer with ultrasonic activation + gutta-percha cones. The canals were re-instrumented with Largo burs, followed by the instrument R50 (0.50/0.05) of the Reciproc system. The time required to perform re-instrumentation was recorded (s). The roots were longitudinally cleaved, and the total area of root canal and remaining filling material were quantified (%). The ANOVA test was applied to the data and complemented by Student’s t test (P< 0.05).

Uact group had higher percentage of remaining filling material than NUact group (P < 0.05). When the root thirds were considered, there was statistically significant difference only for Uact group at the apical third (P < 0.05). There was no difference between groups regarding the time required to perform re-instrumentation (P > 0.05).

Ultrasonic activation of sealer leads to a higher percentage of remaining filling material attached to the root canal walls. However, it did not affect the retreatment time.

Ultrasonic activation increases sealer penetration into dentinal tubules, improving its resistance to dislodgement. However, there is no scientific evidence to prove if ultrasonic activation of sealer hinders its removal when root canal retreatment is necessary.

Ultrasonic activation increases sealer penetration into dentinal tubules, improving its resistance to dislodgement. However, there is no scientific evidence to prove if ultrasonic activation of sealer hinders its removal when root canal retreatment is necessary.

The purpose of this present study was to evaluate the efficiency of the growth factors delivered by concentrated growth factor (CGF) on the healing process of osteoporotic patients with medication-related osteonecrosis of the jaws (MRONJ).

This randomized controlled study was composed of osteoporotic female patients who were treated with oral bisphosphonates (BPs) and diagnosed with MRONJ. For the CGF group, each patient was treated with a local application of CGF at the surgical site after removing the necrotic bone, while the surgical area was primarily closed as traditional surgical therapy for the control group. The patients underwent clinical examinations for 6months postoperatively to check the presence of infection and dehiscence.

Complete healing was achieved in 19 patients of 28 patients (mean age CGF group, 73.57 ± 5.1; control group, 73.64 ± 5.49) diagnosed with MRONJ. There was no significant difference in post-op healing data between groups during healing periods (p> 0.05). In the CGF group (n= 14) in three cases, bone exposure without infection was detected, and one of them showed a recurrent infection. In the control group (n= 14) in six cases, bone exposure without infection was detected, and three of them also showed recurrent infection.

Although our results were not statistically significant, our findings suggest that the local application of CGF appears to be an effective approach to the surgical treatment of MRONJ in osteoporosis patients by improving tissue regeneration.

A specific treatment protocol to manage MRONJ is still controversial. This study justifies that CGF can be used in combination with surgical treatment.

A specific treatment protocol to manage MRONJ is still controversial. This study justifies that CGF can be used in combination with surgical treatment.