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We analyze the flow and clogging of circular grains passing through a small aperture under vibration in two dimensions. Via discrete element method simulations, we show that when grains smaller than the original ones are introduced in the system as an additive, the net flow of the original species can be significantly increased. Moreover, there is an optimal radius of the additive particles that maximizes the effect. This finding may constitute the basis for technological applications not only concerning the flow of granular materials but also regarding active matter, including pedestrian evacuation.We consider a mathematical model that describes the flow of a nematic liquid crystal (NLC) film placed on a flat substrate, across which a spatially varying electric potential is applied. Due to their polar nature, NLC molecules interact with the (nonuniform) electric field generated, leading to instability of a flat film. Implementation of the long wave scaling leads to a partial differential equation that predicts the subsequent time evolution of the thin film. This equation is coupled to a boundary value problem that describes the interaction between the local molecular orientation of the NLC (the director field) and the electric potential. We investigate numerically the behavior of an initially flat film for a range of film heights and surface anchoring conditions.Nonreciprocity is of particular importance to realize one-way propagation, thus attracting intensive research interest in various fields. Thermal waves, essentially originating from periodic temperature fluctuations, are also expected to achieve one-way propagation, but the related mechanism is still lacking. To solve the problem, we introduce spatiotemporal modulation to realize thermal wave nonreciprocity. Since thermal waves are completely transient, both the convective term and the Willis term induced by spatiotemporal modulation should be considered. We also analytically study the phase difference between two spatiotemporally modulated parameters, which offers a tunable parameter to control nonreciprocity. We further define a rectification ratio based on the reciprocal of spatial decay rate and discuss nonreciprocity conditions accordingly. Finite-element simulations are performed to confirm theoretical predictions, and experimental suggestions are provided to ensure the feasibility of spatiotemporal modulation. These results have potential applications in realizing thermal detection and thermal stabilization simultaneously.Phase-field models for strongly anisotropic surface energy need to be regularized to remove the ill posedness of the dynamic equations. Daratumumab chemical structure Regularization introduces a new length scale, the corner size, also called the bending length. For large corner size, with respect to interface thickness, the phase-field method is known to converge asymptotically toward the sharp-interface theory when the appropriate approximation of the Willmore energy is used. In this work we study the opposite limit, i.e., corner size smaller than the interface width, and show that the shape of corners, at equilibrium, differs from the sharp-interface picture. However, we find that the phase transition at the interface is preserved and presents the same properties as the classical problem.Chemotherapeutic resistance via the mechanism of competitive release of resistant tumor cell subpopulations is a major problem associated with cancer treatments and one of the main causes of tumor recurrence. Often, chemoresistance is mitigated by using multidrug schedules (two or more combination therapies) that can act synergistically, additively, or antagonistically on the heterogeneous population of cells as they evolve. In this paper, we develop a three-component evolutionary game theory model to design two-drug adaptive schedules that mitigate chemoresistance and delay tumor recurrence in an evolving collection of tumor cells with two resistant subpopulations and one chemosensitive population that has a higher baseline fitness but is not resistant to either drug. Using the nonlinear replicator dynamical system with a payoff matrix of Prisoner’s Dilemma (PD) type (enforcing a cost to resistance), we investigate the nonlinear dynamics of this three-component system along with an additional tumor growth model whose growth rate is a function of the fitness landscape of the tumor cell populations. A key parameter determines whether the two drugs interact synergistically, additively, or antagonistically. We show that antagonistic drug interactions generally result in slower rates of adaptation of the resistant cells than synergistic ones, making them more effective in combating the evolution of resistance. We then design evolutionary cycles (closed loops) in the three-component phase space by shaping the fitness landscape of the cell populations (i.e., altering the evolutionary stable states of the game) using appropriately designed time-dependent schedules (adaptive therapy), altering the dosages and timing of the two drugs. We describe two key bifurcations associated with our drug interaction parameter which help explain why antagonistic interactions are more effective at controlling competitive release of the resistant population than synergistic interactions in the context of an evolving tumor.We study how a quantum heat engine based on a single trapped ion performs in finite time. The always-on thermal environment acts like the hot bath, while the motional degree of freedom of the ion plays the role of the effective cold bath. The hot isochoric stroke is implemented via the interaction of the ion with its hot environment, while a projective measurement of the internal state of the ion is performed as an equivalent to the cold isochoric stroke. The expansion and compression strokes are implemented via suitable change in applied magnetic field. We study in detail how the finite duration of each stroke affects the engine performance. We show that partial thermalization can in fact enhance the efficiency of the engine, due to the residual coherence, whereas faster expansion and compression strokes increase the inner friction and therefore reduce the efficiency.