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Dupilumab, a monoclonal antibody against interleukin (IL)-4 receptor alpha that inhibits IL-4/IL-13 signalling is indicated in dermatology for the treatment of moderate-to-severe atopic dermatitis (AD) in adult and adolescent patients 12 years and older and severe AD in children 6-11 years, who are candidates for systemic therapy. Dupilumab received Early Access to Medicines Scheme (EAMS) approval for adults in March 2017.

The purpose of this study was to assess the efficacy outcomes of treatment with dupilumab in EAMS.

A retrospective analysis of adult patients enrolled in the dupilumab EAMS in the UK. Scores were assessed at baseline and follow up, including the Eczema Area and Severity Index (EASI), Investigator’s Global Assessment Score (IGA) and Dermatology Life Quality Index (DLQI).

Data were available for 57 adult patients treated with dupilumab for at least 12 weeks; 73.6% of patients had received prior treatment with 3 or 4 immunosuppressants. Baseline scores for the EASI and DLQI were 27.93 – and physician-reported outcome measures. Importantly, the clinical efficacy, despite the refractory disease of this EAMS cohort, is comparable to that previously reported in clinical trials.Rhabdomyolysis (RML) is a pathological entity characterized by symptoms of myalgia, weakness and dark urine (which is often not present) resulting in respiratory failure and altered mental status. Laboratory testing for myoglobinuria is pathognomonic but so often not present during the time of testing that serum creatine kinase should always be sent when the diagnosis is suspected. Kidney injury from RML progresses through multiform pathways resulting in acute tubular necrosis. Early treatment (ideally less then 6 hoursfrom onset) is needed with volume expansion of all non-overloaded patients along with avoidance of nephrotoxins. There is insufficient data to recommend any specific fluid. The mortality rate ranges from 10% to up to 50% with severe AKI, so high index of suspicion and screening should be in care plan of seriously ill patients at risk for RML.What is scientific progress? This paper advances an interpretation of this question, and an account that serves to answer it (thus interpreted). Roughly, the question is here understood to concern what type of cognitive change with respect to a topic X constitutes a scientific improvement (to a greater or lesser extent) with respect to X. The answer explored in the paper is that the requisite type of cognitive change occurs when scientific results are made publicly available so as to make it possible for anyone to increase their understanding of X. This account is briefly compared to two rival accounts of scientific progress, based respectively on increasing truthlikeness and accumulating knowledge, and is argued to be preferable to both.The objective of this study is to compare the different methods which are effective in predicting data of the short-term effect of COVID-19 confirmed cases and DJI closed stock market in the US. Data for confirmed cases of COVID-19 has been obtained from Worldometer, the database of Johns Hopkins University and the US stock market data (DJI) was obtained from Yahoo Finance. The data starts from 20 January 2020 (first confirmed COVID-19 case the US) to 06 December 2020 and DJI data covers 21 January 2019 to 04 December 2020. COVID-19 data was tested for the period 30 November to 06 December and DJI from 25 November 2020 to 04 December. From the result, we find that the method SutteARIMA was found more suitable to calculate the daily forecasts of COVID-29 confirmed cases and DJI in the US and this method has been used in this study. For the evaluation of the prediction methods, the accuracy measure means absolute percentage error (MAPE) has been used. The MAPE value with the SutteARIMA of 0.56 and 0.60 for COVID-19 and DJI stock respectively was found to be smaller than the MAPE value with ARIMA method.The European Union is an unprecedented unification project that successfully preserves political peace and integrates Europe’s countries into a supra-national model. However, recent economic and political crises have shown that there are institutional problems that have undermined the EU and lost the trust of many citizens. In Italy after the ‘political earthquake’ of the 2013 national elections, the party system suffered a further shock in 2018 with the consolidation of the centre-right and Five Star Movement as the main competing political actors. In this context, the relationship with the EU has undergone numerous tensions, impacting directly on Italian public opinion and its perception of European institutions. This paper investigates whether and how the ‘exit’ issue from the EU affects Italian citizens, particularly how they react to a UK-style hypothetical referendum on leaving the EU. By analysing a 2019 voter study, it tries to identify clusters of Italian citizens by their attitude to European policies and a possible EU referendum.Amid the spread of COVID-19, a study of mental health in university students from different regions of Russia (n = 3057) was undertaken during the period from April 9 to April 20, 2020. The results were compared to studies conducted earlier within a large-scale research project examining student mental health. Mental health indicators were analyzed during three different periods long before the onset of the pandemic (period 1); in the early days of the spread of COVID-19 in Russia, though prior to the implementation of containment measures (period 2); during tough measures to contain the first wave of the pandemic (period 3). The comparison of indicators showed no differences in the levels of psychological well-being (F = 0.918; p = .4), significantly lower levels of depression, anxiety and stress during the period 1 compared to the periods 2 and 3 (p  less then  .001), and the highest levels of anxiety and stress during the period 2. We also established a higher increase in the levels of depression (F = 6.883; p = .001), anxiety (F = 11.868; p  less then  .001) and stress (F = 10.384; p  less then  .001) in young men compared to the changes in the same indicators in young women during the pandemic. However, both before and during the pandemic, these indicators showed better mental health in young men than in young women. Thus, when studying the impact of the pandemic on students’ mental health, it is crucial to take into account the possible dynamics of their mental state within relatively short periods of time and to pay particular attention to gender differences.The study focuses on psychological-linguistic analysis of utterances provided by N = 2522 respondents aged 18-89 years in the period of March-May 2020, for the research of JUPSYCOR (Psychological Impacts of the Coronavirus Epidemic in the Czech Republic). The utterances relate to the interpretation of the state of emergency, the COVID-19 epidemic, and its subjectively perceived impacts. Simultaneously, the study examines the relationship between the analysed texts and the results of the SEHW (Scales of Emotional Habitual Subjective Well-being) questionnaire, which determines the valence of experienced emotions. The aim of the study is to analyse the lexical and morphological layers of the utterances, especially which specific words resonated in the individual questions, what is their emotional load, and which linguistic features of the texts may refer to the respondents’ positive/negative emotional response. One of the outputs based on the results of the quantitative analyses determines that the most distinctive words are connected to negative emotions and most frequently relate to social environment, anxiety, and inhibition. Furthermore, the study proves a positive correlation between a fear scale and a higher occurrence of future tense and use of emotionally negatively loaded words, especially in women. Numerous differences among the individual age and gender cohorts were also proved. The significance of the study lies predominantly in the combination of the linguistic and psychological levels of the analysis, in the utilization of two mutually complementary utterances, and in the presentation of new insights on how people use words when they face an unexpected and emotionally disturbing situation.

The online version contains supplementary material available at 10.1007/s12646-021-00613-y.

The online version contains supplementary material available at 10.1007/s12646-021-00613-y.As the world comes to terms with the changes brought on by the appearance and spread of Covid-19, there is an increase in fear and anxiety levels. The World Health Organization has stressed on the need to focus on mental health, as the epidemic affects both young and old. One of the biggest challenges is that the situation has no precedent. This has led to the creation of uncertainty and doubt. The current study focusses on studying the positive mental health of the Indian population. For the study, the researchers have restricted the scope to include only Generation Y and Generation Z, as they form a majority of the working population and literature suggests that negative moods, stressors and apprehensions are far more prevalent among the younger sections of the society. The findings suggest that positive mental health is not dependent on gender or age. However, some of the dimensions do show significant variance. The researchers have also proposed a model of Positive Mental Health based on the dimensions of the Positive Mental Health Instrument.Insulin pumps and glucose sensors have been shown to be effective in improving diabetes treatment and reducing acute complications according to data from registries. Therefore, in pediatric diabetology the use of at least one technical device is standard. Both devices can also be combined to form automated insulin delivery (AID) systems.Many AID systems have been tested in clinical trials and have proven to be safe and effective. The supply situation in Germany currently only allows one system to be prescribed for people insured by the statutory health insurances. buy Mycophenolate mofetil Currently, children younger than 7 years of age cannot be treated with this system. The reasons for this are legal hurdles and lack of certification by the manufacturers. The CE certification can also lead to problems with insulin prescriptions. Open-source systems are non-regulated variants to circumvent existing regulatory conditions. There are risks here for both users and prescribers.For permanent use a thorough knowledge of the features of each AID system is necessary for both the user and the practitioner. Complete automation does not yet work. For the evaluation of the AID treatment, the metric data of the glucose sensors, the time in range and the glucose management index are the recognized and suitable parameters, because they allow a consultation based on real data from the daily life of people with diabetes.As all glucose sensors are read out via cloud-based software or the data are obtained directly and automatically from a telephone-linked receiver device, this provides the ideal technical basis for telemedical care, which still needs to be configured.