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A standardized definition and understanding of relapse not only minimize confusion, inconsistency, and social and self-stigma associated with the term but also helps provide relapse-sensitive care with accurate methods of assessment and evaluation. © 2020 Wiley Periodicals, Inc.BACKGROUND AND OBJECTIVES Red-blood-cells (RBCs) undergo structural and metabolic changes with prolonged storage, which ultimately may decrease their survival after transfusion. Although the storage-induced damage to RBCs has been rather well described biochemically, little is known about the mechanisms underlying the recognition and rapid clearance of the damaged cells by macrophages. MATERIALS AND METHODS We, here, used a murine model for cold (+4°C) RBC storage and transfusion. Phagocytosis of human or murine RBCs, liquid stored for 6-8 weeks or 10-14 days, respectively, was investigated in murine peritoneal macrophages. RESULTS The effects of storage on murine RBCs resembled that described for stored human RBCs with regard to decreased adenosine triphosphate (ATP) levels, accumulation of microparticles (MPs) during storage, and RBC recovery kinetics after transfusion. Under serum-free conditions, phagocytosis of stored human or murine RBCs in vitro was reduced by 70-75%, as compared with that in the presence of heat-inactivated fetal calf serum (FCS). Human serum promoted phagocytosis of stored human RBCs similar to that seen with FCS. By adding fucoidan or dextran sulphate (blockers of scavenger receptors class A (SR-A)), phagocytosis of human or murine RBCs was reduced by more than 90%. Phagocytosis of stored human RBCs was also sensitive to inhibition by the phosphatidylinositol 3 kinase-inhibitor LY294002, the ERK1/2-inhibitor PD98059, or the p38 MAPK-inhibitor SB203580. CONCLUSION RBCs damaged during liquid storage may be recognized by macrophage SR-A and serum-dependent mechanisms. This species-independent recognition mechanism may help to further understand the rapid clearance of stored RBCs shortly after transfusion. © 2020 The Authors. Vox Sanguinis published by John Wiley & Sons Ltd on behalf of International Society of Blood Transfusion.Previous research has shown that there is higher tolerance of violence against women in cultures with salient gender-specific honor norms, especially when the violence occurs in intimate relationships and in response to threat to male honor. The present cross-cultural study (N = 398) extended these findings to sexual aggression (i.e., marital rape) by comparing participants from a culture that emphasizes honor (Turkey) and participants from cultures without strong honor traditions (Germany and Britain). Turkish participants blamed the victim and exonerated the perpetrator more than did German and British participants. In all cultural groups, participants blamed the victim and exonerated the perpetrator more when the husband’s reputation was threatened than in the absence of such threat, and in all cultural groups, men blamed the victim and exonerated the perpetrator more than women. Yet, the effect of masculine reputation threat and this pattern of gender differences were somewhat more pronounced among Turkish than German or British participants. Results exploring the predictive role of honor norms at the individual level beyond rape myth acceptance and traditional gender role attitudes revealed that honor norms were the primary predictor of rape perceptions and blame attributions in Turkey (an honor culture), but not in Germany and Britain (dignity cultures) where rape myth acceptance was the strongest predictor. These results provide insights into the cultural factors influencing marital rape judgments in ways that may undermine victim’s well-being and fair handling of rape cases, and highlight the domains most urgently in need of potential intervention. © 2020 The Authors. Aggressive Behavior published by Wiley Periodicals LLC.BACKGROUND AND OBJECTIVES The aim of this study was to determine whether the administration of neoadjuvant therapy (NAD) affects the incidence, timing, and pattern of recurrence in patients treated by curative gastrectomy. METHODS Sixty-nine patients undergoing NAD and R0 gastrectomy were compared with 198 patients undergoing upfront surgery using the propensity score matching (PSM) method. Disease-free survival (DFS), disease-specific survival (DSS), and progression-free survival (PFS) analyses were conducted with a log-rank test and Cox regression. Risk factors for recurrence were assessed by logistic regression. RESULTS Among 69 patients with NAD, 28 (40.6%) experienced recurrence, and signet-ring cell (SRC) carcinoma was the only factor independently associated with recurrence. In the whole sample, NAD did not influence DFS, DSS, rate of recurrence, or PFS. After PSM, the variables associated with DFS were cN1, type of gastrectomy, the presence of SRCs, and the presence of lymphovascular invasion. Variables independently associated with recurrence were cN1, type of gastrectomy, and the presence of SRCs. CONCLUSIONS NAD had no impact on DFS, DSS, or the pattern of recurrence in any patients with gastric cancer. To define a better treatment strategy, future studies should focus on subtypes that do not respond to the current neoadjuvant regimens. Thiamet G research buy © 2020 Wiley Periodicals, Inc.PURPOSE Smoking is a well-known risk factor for coronary artery diseases. It is also associated with nicotine-induced myocardial dysfunction. The aim of this study was to evaluate the right and left atrial and ventricular functions in apparently healthy smokers. METHODS We included consecutively 80 healthy smokers (56 males, mean age35.5 ± 8.4 years) and 70 healthy nonsmokers (44 males, mean age33.9 ± 9.5 years). None of the subjects had any additional cardiovascular risk factor other than smoking. The right and left atrial and ventricular functions were assessed by both conventional and speckle tracking echocardiography. RESULTS Although there was no significant difference in left ventricular ejection fraction, the smokers had significantly lower ventricular global longitudinal strain than controls (-19.9 ± 2.0% vs -21.2 ± 1.9%, P  less then  .001 and -18.4 ± 2.1% vs -21.8 ± 2.2%, P  less then  .001, respectively, for the left and right ventricle). Smokers had also lower atrial reservoir and conduit strains 35.