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The variables consolidation, boundary feature, large cable sign and crazy-paving sign were the most significant factors, based on a variable named “prediction of progression or remission” (PPR) that we constructed. The ROC curve showed that PPR had an AUC of 0.882 (cutoff value=0.66, sensitivity=0.75, specificity=0.875).

CT characteristics, in particular, round shape, GGO, consolidation, large cable sign, and crazy-paving sign, may increase the recognition of the intrapulmonary development of COVID-19.

CT characteristics, in particular, round shape, GGO, consolidation, large cable sign, and crazy-paving sign, may increase the recognition of the intrapulmonary development of COVID-19.This analysis was inspired by the recent paper by Siomava et al. (2020) who attempted to deconstruct the serial homology concept, but retain the special homology. The criticism against this attempt is presented based on reconsideration of the original Owen’s trinitarian concept of the general, serial, and special homology, and on a number of evidence on the vertebrate limbs serial homologies and on the vertebrate occiput special homologies which are currently missed by the morphologist community. The research of Belogolowy (1911) proved that the concept of special homology can be deconstructed with the same reasoning as suggested by Siomava et al. (2020) against the serial homology concept. It is argued that the deconstruction attempts come from wrong expectations in respect of homology. It is argued, that, due to developmental singularities, such as the zygote, or spore, or bud (in vegetative reproduction), the true homogeny is possible for genes only. The organs do not arise from organs, and therefore their genetic basis, and hence homology, can be changed in the developmental singularities. Thus, the morphological homology is not static. It can be acquired and it can evolve. Genetically, the evolution of morphological homologies can be thought of as a succession of co-options. The evidence for a succession of serial homologies in vertebrate limbs is suggested. It is argued that homology and analogy have a sense only in relation to each other. When two correspondences between two organs exist simultaneously, the older (deeper in time) is homology, and the newer (more superficial) is analogy. In this conceptual framework of evolvable homology, neither of the three Owen’s types of homology can be abandoned. Three respective types of analogy should be added-the general analogy, the serial analogy, and the special analogy.Cardiac allograft vasculopathy (CAV) is mediated by endothelial inflammation, platelet activation and thrombosis. Antiplatelet therapy may prevent the development of CAV. This systematic review and meta-analysis summarizes and appraises the evidence on the effect of antiplatelet therapy after heart transplantation (HT). CENTRAL(Ovid), MEDLINE(Ovid), Embase(Ovid) were searched from inception until April 30, 2020. Outcomes included CAV, all-cause mortality, and CAV-related mortality. Data were pooled using random-effects models. Seven observational studies including 2023 patients, mean age 52 years, 22% female, 47% with ischemic cardiomyopathy followed over a mean 7.1 years proved eligible. All studies compared acetylsalicylic acid (ASA) to no treatment and were at serious risk of bias. Data from 1911 patients in 6 studies were pooled in the meta-analyses. The evidence is very uncertain about the effect of ASA on all-cause or CAV-related mortality. ASA may reduce the development of CAV (RR 0.75, 95% CI 0.44-1.29) based on very low certainty evidence. Two studies that conducted propensity-weighted analyses showed further reduction in CAV with ASA (HR 0.31, 95% CI 0.13-0.74). click here In conclusion, there is limited evidence that ASA may reduce the development of CAV. Definitive resolution of the impact of antiplatelet therapy on CAV and mortality will require randomized clinical trials.Lymphoma is the most common haematological malignancy in dogs and its aetiology is largely unknown. The presence of canine vector-borne agents (CVBD) in lymphoma tissues has been described and its causative effects questioned. We intended to evaluate the presence and extent of Leishmania infantum, Ehrlichia canis, Anaplasma phagocytophilum and Bartonella henselae infection in dogs with lymphoma. Sixty-one dogs, living in the Lisbon metropolitan area, with a diagnosis of lymphoma were enrolled. Immunofluorescence assays were used to detect serum IgG’s. The presence of DNA from CVBD agents in tumour tissue was assessed by PCR. All dogs tested negative for B. henselae, A. phagocytophilum and E. canis by both serology and PCR. Regarding L. infantum, 8.2% (n = 5) of the dogs had a positive serologic result. L. infantum DNA was detected in two samples of diffuse large B-cell lymphoma (DLBCL). These results show an increased, but not significant, seropositivity (8.2% vs 7.9%) and molecular detection (3.3% vs 1.2%) for L. infantum in dogs with lymphoma, when compared to the reported canine population in the same geographical area. We could not identify an association between lymphoma and E. canis, A. phagocytophilum, B. henselae or Leishmania infantum infection in the studied population. Nevertheless, further studies, following dogs trough their CVBD disease evolution, are worthwhile and may help clarify a possible role of CVBD agents in lymphomagenesis.

Multidrug-resistant tuberculosis (MDR-TB) is a major global public health concern. However, there is a dearth of literature on whether MDR-TB and its medications impact maternal and perinatal outcomes, and when such evidence exists the findings are conflicting.

This systematic review and meta-analysis aimed to examine the impact of MDR-TB and its medications during pregnancy on maternal and perinatal outcomes.

PubMed, Scopus and Web of Science databases were searched from earliest to February 2020.

Records were screened based on pre-defined selection criteria and assessed for quality by two independent reviewers.

A meta-analysis was performed using the random effects model to calculate pooled prevalence for each outcome.

Of the 72 records identified, 12 were included in the systematic review and meta-analysis, consisting of 174 pregnant women with MDR-TB and 110 adverse outcomes. Maternal death, pregnancy loss, preterm birth and low birthweight were the most common maternal and perinatal adverse outcomes reported in the studies.