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Tuberculous pericarditis is a severe form of extrapulmonary tuberculosis and is the commonest cause of pericardial effusion in high incidence settings. Mortality ranges between 8 and 34%, and it is the leading cause of pericardial constriction in Africa and Asia. Current understanding of the disease is based on models derived from studies performed in the 1940-50s. This review summarises recent advances in the histology, microbiology and immunology of tuberculous pericarditis, with special focus on the effect of Human Immunodeficiency Virus (HIV) and the determinants of constriction. When asked to say whether an agent is morally good or bad, younger preschoolers tend to rely more on the outcomes of agents’ actions than on agents’ intentions, whereas older children show the opposite bias. Children aged 3 to 5 years were examined with a novel task that facilitated the selection and expression of response by means of response generation training. In two experiments, we found that 3-year-olds succeeded in generating intent-based judgments when the task was simplified, whereas older preschoolers succeeded also without the help of response generation training. Results are inconsistent with views positing a conceptual change occurring in the moral domain at about 4 years of age and provide support for alternative accounts positing conceptual continuity. Theory of mind has received intensive attention in research as an important skill to develop. Furthermore, recent evidence indicates its role in discourse comprehension. In the current study, we examined the mediating role of theory of mind in the relations of foundational language and cognitive skills (working memory, attentional control, vocabulary, and grammatical knowledge) to discourse comprehension using the direct and indirect effects model of text comprehension and production (Kim, 2016) as a theoretical framework, and using longitudinal data from kindergarten to Grade 2. Structural equation model results showed that theory of mind partially mediated the relations in both grades, and the effects (standardized regression weights) were similar in kindergarten and Grade 2. Interestingly, the relations of language and cognitive skills to theory of mind differed in kindergarten versus Grade 2. Language and cognitive skills had moderate to strong longitudinal stability, and these skills in kindergarten were indirectly related to discourse comprehension in Grade 2 via the language and cognitive skills in Grade 2. These results support the mediating role of theory of mind as well as the nature of structural and longitudinal relations among language and cognitive skills and to discourse comprehension. Lignocellulose comprises a significant portion of municipal solid waste (MSW) – 40-70% in developed countries, including paper, wood, and yard waste. Cellulose and hemicellulose are often shielded by lignin, posing a barrier to waste decomposition and landfill gas generation. Unfortunately, lignin is resistant to microbial degradation under low-oxygen conditions that normally occur in MSW landfills. The bacterium strain TAV5, microaerophilic and member of phylum Verrucomicrobia, isolated from the hindgut of the Reticulitermes flavipes termite, the most widely distributed subterranean termite in North America. Its genome contains genes associated with methylotrophic competency which code for enzymes that structurally modify lignin. The overall goal of this research was to use TAV5 to modify lignin and boost methane production from MSW. Batch-scale reactors (125 mL) were filled with paper, yard, or wood waste, and four ratios of mixed of waste. Reactors were seeded with different ratios of TAV5 to anaerobic digester (AD) microorganisms (representing landfill anaerobic microorganisms). Based on batch tests, optimal ratios of TAV5 to AD microorganisms were used to seed wastes (mixed, yard, and wood) in 6-gallon reactors. Addition of TAV5 increased methane production from mixed waste, yard waste, and wood, by 49%, 34%, and 297%, respectively. TAV5 decreased acid soluble lignin by 7-39%, depending on waste type. TAV5 grown under aerobic conditions and room temperature (not requiring a heated anaerobic chamber) was found to remain viable and increase methane production under low-level oxygen conditions (1-2%). This finding will potentially lessen costs for growing large volumes of it for seeding landfills. A novel heavy metal chelating agent, dithiocarboxylate-functionalized polyaminoamide dendrimer (PAMAM-0G-DTC), was evaluated for the stabilization of heavy metals from municipal solids waste incineration (MSWI) fly ash. PAMAM-0G-DTC achieved overall stabilization performance at a lower dosage (3% w/w) and a wider pH range (2-13) compared to conventional chelating agents such as sodium dimethyl dithiocarbamate (SDD) and dithiocarboxylate-functionalized tetraethylenepentamine (TEPA-DTC). EN4 The leaching toxicity of Pb and Cd in the MSWI fly ash by PAMAM-0G-DTC stabilization met the landfill requirements but could not be achieved by SDD and TEPA-DTC even at a 10 wt% concentration. Sequential chemical extraction of fly ash before and after stabilization shows that PAMAM-0G-DTC can be combined with active heavy metals in water-soluble, interchangeable, and carbonate states to form more stable heavy metals in organic and residual states. Mechanistic studies show that multiple PAMAM-0G-DTC molecules can combine with multiple heavy metals to form three-dimensional network-like super-molecular compounds with an infinite extension of space size. This makes the heavy metals more stable and embedded in the network-like super-molecular structure, thus minimizing the potential risk of leaching. Overall, by forming more geochemically stable phases, the treatment of fly ash with PAMAM-0G-DTC has a strong ability to reduce the toxic leaching of heavy metals at a lower dosage and suppress the risk of secondary pollution in a landfill at a wide range of pH values (2-13). Co-digestion of blackwater (BW) and organic kitchen waste (KW) is a promising and effective resource-recovery based approach for municipal waste and wastewater treatment. In this study, anaerobic co-digestion treatments of BW and KW using anaerobic sequencing batch reactors under mesophilic and thermophilic conditions were compared. Our results showed that although higher sludge specific methanogenesis activities were observed in the thermophilic reactor, mesophilic treatment achieved significantly higher treatment capacity and methane production. It was concluded that thermophilic conditions introduced H2 inhibition and reduced activities of syntrophic acetogenic bacteria and syntrophic acetate oxidizing bacteria in the reactor. Further investigation on microbial communities showed significantly different microbial communities between reactors, where Thermotogaceae and Methanothermobacter were the most prevalent bacteria and archaea in the thermophilic reactor, and Cloacamonaceae and Methanosarcina were the most prevalent ones in the mesophilic reactor. Aphanamoxene A-D (1-4), three new acyclic diterpene derivatives and one new acyclic norsesquiterpene were isolated from the seed of Aphanamixis polystachya. Their structures were elucidated on the basis of extensive spectroscopic methods, including 1D and 2D NMR and HRESIMS. And the absolute configuration of 1 was achieved by Mosher method. These acyclic terpenoids (1-4) showed obvious nitric oxide production inhibitory activity on lipopolysaccharide-Induced RAW264.7 macrophages with IC50 values of 17.6 ± 1.4, 9.8 ± 0.7, 16.6 ± 1.2, and 14.2 ± 0.9 μM, respectively. Five new alkaloidal metabolites cordycepamides A-E (1-5), and one glycoside metabolite cordyglycoside A (6), together with six known compounds (7-12) were isolated from the entomopathogenic fungus Cordyceps sp. (LB1.18060004) from unidentified insect collected in Baoshan City, Yunnan Province, People’s Republic of China. The structures were characterized by NMR and HRESIMS spectroscopic analyses. Cordycepamides A and B (1 and 2) were mixtures of two isomers in 54 ratio by integration of 1H NMR spectra. In additional, the structure of cordycepamide A (1) was further confirmed by X-ray crystallography as a pair of enantiomers. Absolute configurations of sugar moiety of cordyglycoside A (6) was confirmed by the acid hydrolysis and subsequent HPLC analysis. The isolated metabolites were evaluated for antimicrobial, cytotoxicity, and the DPPH scavenging assay, only 4 showed modest antioxidant effects in the DPPH scavenging assay (IC50 = 51.42 ± 3.08 μM). Five new cadinene-type sesquiterpenes, hibiscusterpenes I-V (1-5), and six known compounds (6-11) have been isolated from the methanol extract of the stems and the twigs of Hibiscus tiliaceus. The structures of the new compounds were elucidated based on chemical and spectroscopic evidence. The absolute stereochemistry of hibiscusterpene I (1) was determined using X-ray crystallography. For hibiscusterpene III (3), the absolute configuration was established upon comparison of the experimental and predicted electronic circular dichroism (ECD) data. Among the isolated compounds, hibiscone C (7) and syriacusin A (11) showed cytotoxic activity in HeLa cells. In addition, their cell death-inducing activity was observed using time-lapse cell imaging. The seeds of Quercus serrata Thunb. (acorns) have been served as a healthy food in Asia. In this study, five previously undescribed triterpenoids, along with nineteen known triterpenoids were isolated from acorns. Their structures were identified on account of spectroscopic analysis and GC-MS analysis after acid hydrolysis. Meanwhile, the inhibitory effects on nitric oxide (NO) production induced by lipopolysaccharide (LPS) in microglia cells (BV-2) of the identified triterpenoids were evaluated. All these compounds revealed overt anti-neuroinflammatory activity expect for 7. Compounds 1, 16 and 17 had potent inhibitory effects on protein and mRNA expression of iNOS and COX-2 in LPS-induced BV-2 cells. Bioactive triterpenoids 1, 2, 16 and 17 could block LPS-induced NF-κB nuclear translocation. This study suggested that acorns could be served as natural healthy product against neuroinflammatory-associated diseases, such as Alzheimer’s disease. Nearly half (45%) of the human genome is composed of transposable elements, or ‘jumping genes’. Since Barbara McClintock’s original discovery of transposable elements in 1950, we have come to appreciate that transposable element mobilization is a major driver of evolution that transposons are active in the germline and the soma, and that transposable element dysregulation is causally associated with many human disorders. In the present review, we highlight recent studies investigating transposable element activation in the adult brain and in the context of neurodegeneration. Collectively, these studies contribute to a greater understanding of the frequency of complete retrotransposition in the adult brain as well as the presence of transposable element-derived RNA and protein in brain and fluids of patients with neurodegenerative disorders. We discuss therapeutic opportunities and speculate on the larger implications of transposable element activation in regard to current hot topics in the field of neurodegeneration.