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The doctors identified the patient’s pattern as “spleen-stomach weakness”, “liver qi depression”, or “food accumulation or phlegm-fluid retention”. The most frequently selected acupoints were CV12, LI4, LR3, ST36, and PC6. Conclusion There are common acupoints across different patterns, but pattern-specific acupoints were also recommended. These results can provide useful information to design clinical research and education for better clinical performance in acupuncture that reflects real-world practice.Background This study aims to review the current quantity and quality of case reports and case series published by clinical doctors who worked in local Korean medicine clinics. Methods Seven electronic databases, one in English and six in Korean, were searched for case studies authored by clinically-based Korean Medicine doctors (KMDs) and published in academic journals between January 2000 and December 2018. The following data were extracted the number of cases per article, authorship order, types of academic journals, the number of articles published in the domestic or international academic journals by publication year, citation counts, and classification of diseases. We assessed the quality of the reports based on 28 items from the CAse REport (CARE) checklist. Results A total of 266 case reports or case series met the inclusion criteria. There were 125 articles (47.0%) in which all authors consist of who worked in Korean medicine clinics. The overall increase in the number of published articles by year showed a sharp increase after 2010. Articles were focused primarily on Korean medicine therapeutic and diagnostic approaches. The most commonly reported cases were diseases of the skin (346 or 40.9%). Overall, the quality of the reports was acceptable (75.3%) but several items such as diagnostic challenges, patient perspective, informed consent, intervention adherence and tolerability, and adverse events were substantially underreported. Conclusions To improve disease diagnosis and treatment, KMDs in clinical practice should be encouraged to report and publish case studies, using the CARE checklist to ensure quality.Background Some of the most debilitating symptoms of fibromyalgia (FM) include widespread chronic pain, sleep disturbances, chronic fatigue, anxiety, and depression. Yet, there is a lack of effective self-management exercise interventions capable of alleviating FM symptoms. The objective of this study is to examine the efficacy of a 10-week daily Qigong, a mind-body intervention program, on FM symptoms. Methods 20 participants with FM were randomly assigned to Qigong (experimental) or sham-Qigong (control) groups, with participants blinded to the intervention allocation. The Qigong group practiced mild body movements synchronized with deep diaphragmatic breathing and meditation. The sham-Qigong group practiced only mild body movements. Both groups practiced the interventions two times per day at home, plus one weekly group practice session with a Qigong instructor. Primary outcomes were pain changes measured by the Short-Form McGill Pain Questionnaire, a visual analog scale for pain, pressure pain threshold measured by a dolorimeter. Secondary outcomes were the Revised Fibromyalgia Impact Questionnaire the Pittsburgh Sleep Quality Index, the Hospital Anxiety and Depression Scale and the Quality of Life Scale. Results The experimental group experienced greater clinical improvements when compared to the control group on the mean score differences of pain, sleep quality, chronic fatigue, anxiety, depression, and fibromyalgia impact, all being statistically significant at p less then 0.05. Conclusion Daily practice of Qigong appears to have a positive impact on the main fibromyalgia symptoms that is beyond group interaction. Trial registration ClinicalTrials.gov NCT03441997.Emergency departments are facing an unprecedented challenge in dealing with patients who have coronavirus disease 2019 (COVID-19). The massive number of cases evolving to respiratory failure are leading to a rapid depletion of medical resources such as respiratory support equipment, which is more critical in low- and middle-income countries. In this context, any therapeutic and oxygenation support strategy that conserves medical resources should be welcomed. Prone positioning is a well-known ventilatory support strategy to improve oxygenation levels. Self-proning can be used in the management of selected patients with COVID-19 pneumonia. Here, we describe our experience with two COVID-19-positive patients who were admitted with respiratory failure. The patients were successfully managed with self-proning and noninvasive oxygenation without the need for intubation.Parathyroid crisis, which might occur during the natural history of primary hyperparathyroidism, presents fatal hypercalcemia. Although hyperparathyroidism is known to cause metastatic pulmonary calcification, parathyroid crisis with respiratory failure is rarely reported. Here, we present a case of parathyroid crisis with respiratory failure due to parathyroid adenoma. For the first 2 weeks after admission to our hospital, the patient was treated with hydration, calcium-lowering agents, dialysis and extracorporeal membrane oxygenation, with gradual improvement in her respiratory condition as blood calcium levels decreased. However, she still needed oxygen even after that. Therefore, parathyroidectomy was performed on day 48, and she no longer needed oxygen after the surgery. Chest computed tomography scan also demonstrated improvement in pulmonary calcification, although it did not completely disappear even 4 months after parathyroidectomy. Parathyroid crisis is an endocrine emergency, and its possibility should be considered in patients with respiratory failure with hypercalcemia.Background Lobular capillary hemangiomas (LCH) are acquired benign vascular lesions of the skin and mucous membranes mostly affecting the head and neck region. Involvement of the nasal cavity is extremely rare and can manifest as epistaxis and nasal obstruction. Case series In this case series, we present five cases of intranasal LCH. Three cases are of pregnant women that presented with epistaxis and nasal obstruction. The first was surgically treated during her pregnancy with preoperative embolization of the tumor for vascular control, while the other two patients were treated after delivery. The two other cases are of a post trauma pediatric patient, and an elderly lady with multiple co-morbidities, both presenting with recurrent nose bleeds and nasal obstruction. Selleckchem GW6471 Surgical excision was performed with no complications observed post-operatively. Discussion The etiology of LCH is unknown, but certain predisposing factors have been associated with the development of LCH and include pregnancy and trauma. The anterior portion of the nasal septal mucosa and the tip of the inferior turbinate are commonly involved sites. Computed tomography scans and histopathology are used to diagnose LCH. Treatment is surgical excision with or without pre-operative embolization. Conclusion LCH are rare tumors of the nasal cavity. Treatment of these lesions is surgical with or without preoperative vascular control.Evacuation drills may constitute a key activity for preparing for an emergency due to an earthquake. The paper presents the results of an analysis of participants’ motivations on the factors leading to conducting drills on 19 September every year in Mexico City; the sample size considered for the analysis was N = 2400. In particular, the following research question has been addressed What factors predict the likelihood that respondents would report that they agree on conducting mass evacuation drills yearly? The approach has been the application of logistic regression technique to identify these factors. Of the 19 initial explanatory variables, in the final model, only seven variables and one interaction term, were significantly associated with the outcome variable; i.e. age (Odds Ratio (OR) = 1.366; 95% Confidence Interval (CI) = 1.039-1.795); occupation (OR = 3.378; CI = 1.457-7.830); frequency of drills one/year (OR = 2.128; CI = 1.610-2.812); knowledge vs. drills (OR = 1.394; CI = 1.172-1.658); ‘perception vulnerability city’ (OR = 1.271; CI = 1.091-1.480); warning time (OR = 1.266; CI = 1.1036-1.548); usefulness of the SASMEX (OR = 0.783; CI = 0.615-0.998); and ‘perception vulnerability city’ by occupation interaction (OR = 0.786; CI = 0.643-0.961). Further research may be needed to gain a better understanding of people’s motivations on evacuation drills taking place anytime during the day or at night, and whether evacuation drills should be unannounced.Sedentary screen-time is an increasingly prevalent behaviour, associated with a range of adverse health outcomes. Sedentary time and screen-use increase during adolescence, making this age group a prime target for behaviour change interventions. Better understanding the context in which sedentary screen-behaviours occur is important for ensuring future interventions have maximum impact. This study aimed to describe the prevalence of adolescents’ sedentary screen-time in the after-school and weekday evening periods, and to examine associations between contextual factors (location within the home and who they were with) and after-school/evening screen-time. Time that UK adolescents (N = 204, aged 11 or 12 years, 61.4% girls) spent using various screens was measured using a detailed three-day time-use diary completed at home. Adolescents reported the start and end time for each screen-based activity, where they were, and who they were with. Weekday (Monday-Friday) data were analysed with a focus on the after-school (3-6 pm) and evening periods (6-10.45 pm). Young adolescents spend around a third of their weekday evening leisure-time using screens, with boys engaging in slightly more screen-use than girls. The majority of after-school and weekday evening time at home was spent with family or siblings, with less than 1% spent with friends. Adolescents who spent more time alone after school reported greater screen-use. Greater time spent at home, in the lounge (living room) or bedroom was associated with greater screen-use. These findings highlight the value of devising family-based health-promotion interventions which target after-school/leisure-time screen-use in an effort to reduce young adolescents’ sedentary recreational screen-time behaviours.Background Nifedipine-induced gingival overgrowth (NGO) is a multifactorial pathogenesis with increased extracellular matrix including collagen and glycans, inflammatory cytokines, and phenotype changes of fibroblasts. However, the molecular etiology of NGO is not well understood. The objective of this study is to investigate the key genes in the pathogenesis of NGO. Methods In this study, we examined the proliferation and migration abilities of fibroblasts derived from patients with chronic periodontitis, nifedipine nonresponder gingival overgrowth, gingival overgrowth caused by nifedipine, and healthy normal gingiva. We conducted RNA-Seq on these four groups of fibroblasts and analysed the differentially expressed genes (DEGs). Results Fibroblasts derived from NGO patients had higher proliferation and migration abilities than those of the other groups. Protein-protein interaction network analysis indicated that TGFB2, ITGA8, ITGA11, FGF5, PLA2G4D, PLA2G2F, PTGS1, CSF1, LPAR1, CCL3, and NKX3-1 are involved in the development of NGO.