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es in a.p. view as with conventional radiographs in a.p. view. • EOS can be safely used for primary assessment of osteoarthritis of the knee. • In the preoperative setting for knee replacement surgery, conventional radiographs in two or three planes of the knee should still be acquired in addition to long-leg EOS images.In a previous version of this publication, the author Mercedes Rodriguez Celin’s name was listed as M.R. Celin.

This study compared our program’s (“InsKid”) capability for measuring the infundibulopelvic angle (IPA) with existing ones.

Prospectively, data from 50 patients with lower pole kidney stones with indications for retrograde intrarenal surgery (RIRS) were collected. All patients underwent computed tomography (CT)-urography. The IPA of each pelvicalyceal (PCS) unit was measured with the Elbahnasy’s, Sampaio’s, and “InsKid” methods. Results were compared. Finally, we compared the area under the receiver operating characteristic (ROC) curve (AUC) for predicting stone-free status after RIRS. We defined success as stone fragments ≤ 2mm on the CT scan on the first postoperative day (POD1). The stone-free rate refers to no identifiable stone fragments on the POD1 CT. Test-retest reliability and face validity were defined to estimate psychometric properties of InsKid.

The success rate after first procedure was 87.5%. The average value of IPA using the Elbahnasy and Sampaio methods and our program were 85.2° ± 11.9°, 95.1° ± 10.1°, and 79.9° ± 13.0, respectively. There was a significant difference among the InsKid, Elbahnasy, and Sampaio (AUC = 0.762, 0.601, and 0.629, respectively) approaches with respect to the capability of predicting the immediate success of RIRS. Repeated measurement did not affect values of IPA (1.3° ± 0.7, p = 0.67). All specialist appreciated proposed software as highly useful (5/5).

This new application reproduces the intraoperative aspects of the PCS more clearly than the other methods and also provides an easy solution for clearly defining the IPA without relying on the central axes.

This new application reproduces the intraoperative aspects of the PCS more clearly than the other methods and also provides an easy solution for clearly defining the IPA without relying on the central axes.This is the first work focused on glycoprofiling of whole N- and O- glycome using lectins in an array format applied for analysis of serum samples from healthy individuals, benign prostate hyperplasia (BPH) patients, and prostate cancer (PCa) patients. Lectin microarray was prepared using traditional lectins with the incorporation of 2 recombinant bacterial lectins and 3 human lectins (17 lectins in total). Clinical validation of glycans as biomarkers was done in two studies discrimination of healthy individuals with BPH patients vs. PCa patients (C vs. PCa) and discrimination of healthy individuals vs. BPH and PCa patients (H vs. PCond). Single lectins (17 lectins) and a combination of two lectins (136 binary lectin combinations) were applied in the clinical validation of glycan biomarkers providing 153 AUC values from ROC curves for both studies (C vs. PCa and H vs. PCond). Potential N- and O-glycans as biomarkers were identified and possible carriers of these glycans are shortly discussed.Changes in pulmonary microhemodynamics during modelling of pulmonary thromboembolism against the background of nebivolol and mirabegron pretreatment were studied in isolated perfused rabbit lungs. In both cases, the pulmonary artery pressure and precapillary and pulmonary vascular resistance increased to a greater extent than in control animals, but the increase in capillary hydrostatic pressure was less pronounced. The postcapillary resistance did not change in pulmonary embolism against the background of nebivolol administration and increased in case of mirabegron pretreatment; capillary filtration coefficient after nebivolol pretreatment increased less markedly than after mirabegron administration. The increase in capillary filtration coefficient after activation of β3-adrenoceptors with the specified drugs depended on the ratio of constriction of pulmonary veins, capillary hydrostatic pressure, and endothelial permeability.

Nivolumab is effective for gastric cancer and lung cancer, but complete response is rare. We experienced a case of synchronous gastric cancer and lung cancer who was treated by nivolumab and laparoscopic gastrectomy.

A 63-year-old male consulted our institution and was found to have gastric cancer cT1(SM)N0M0 Stage IA and lung cancer cT2N2M1(PUL) Stage IV. He received eight chemotherapy treatments plus radiation, but the lung disease remained progressive. Finally, he received nivolumab therapy and complete response of both cancers was obtained. The gastric cancer recurred, but was successfully treated by laparoscopic gastrectomy. The resected specimen revealed three lesions, each being pT1aN0M0 Stage IA. see more The primary gastric cancer seemed to have completely vanished without scarring.

This was thought to be a rare case of gastric cancer recurrence after complete response of gastric cancer and lung cancer to nivolumab.

This was thought to be a rare case of gastric cancer recurrence after complete response of gastric cancer and lung cancer to nivolumab.

To describe the structure-function relationship in birdshot chorioretinopathy (BSCR) using visual field data and peri-papillary retinal nerve fiber thickness (RNFL).

A total of 21 patients (34 eyes) with BSCR were evaluated prospectively from 2014 to 2018 (IMAGE-EYE cohort). Functional tests included measurement of visual acuity and visual field (30-2 SITA standard). Anatomical tests included fluorescein angiography, indocyanine green angiography, and spectral domain optical coherence tomography.

Most of the patients were female (57%) with a mean age of 62 ± 8 years. Mean follow-up was 2.3 ± 0.6 years. Structural examination results were significantly modified in contrast to functional test results, with a significant reduction in mean RNFL (2.49 μm, p < 0.01), temporal RNFL (- 1.68 μm; p = 0.03) and lower nasal RNFL (- 2.83 μm; p = 0.003). A significant linear relationship was found (p = 0.001) between the visual field deficit (mean deviation (MD)) and the Napierian logarithm of the mean RNFL thickness.