Site-Wide Activity

Machine learning is widely used in drug development to predict activity in biological assays based on chemical structure. read more However, the process of transitioning from one experimental setup to another for the same biological endpoint has not been extensively studied. In a retrospective study, we here explore different modeling strategies…[Read more]

Urological guidelines recommend multiparametric magnetic resonance imaging (mpMRI) in men with a suspicion of prostate cancer (PCa). The resulting increase in MRI demand might place health care systems under substantial stress.

To determine whether single-plane biparametric MRI (fast MRI) workup could represent an alternative to mpMRI in…[Read more]

overall health status of the elderly population. However, large-scale clinical studies are needed to confirm our statements.

Localized prostate cancers (PCs) may resist neoadjuvant androgen receptor (AR)-targeted therapies as a result of persistent intraprostatic androgens arising through upregulation of steroidogenic enzymes. Therefore, we…[Read more]

A new kind of feminist citizenship is needed not based on identity but political values.Contraceptive stock-outs are a world-wide problem, yet published research on the impacts of contraceptive stock-outs have not been comprehensively reviewed and synthesised. This systematic review highlights findings about the impacts of contraceptive stock-outs…[Read more]

Conclusions Pretreating with either 20% HF solution at 70-80 °C or 40% HF solution at room temperature and 70-80 °C effectively acid etched the Y-TZP surface, resulting in more surface roughness and irregularities. Accounting for the concentration and temperature conditions of the HF solution, using 40% HF solution at room temperature will r…[Read more]

Despite providing cerebral tissue oxygen saturation (StO

), the lack of quantitative information for continuous wave near-infrared spectroscopy (CW-NIRS) is an obstacle in evaluating cerebral hemodynamic conditions. Time-domain NIRS (TD-NIRS) provides both StO

and cerebral blood volume and has recently become clinically available.…[Read more]

Tephritid fly responses to food-based attractants involve a complex range of food-derived semiochemicals, including ammonia. We performed laboratory and field experiments to compare the attraction of Anastrepha obliqua (Macquart) to ammonia with the attraction to commercial food attractants and torula yeast at a range of pHs. A positive…[Read more]

The Le Fort I maxillary advancement and rotational movement have been adopted to treat patients with cleft-related skeletal Class III pattern and anteromedial cheek soft tissue deficiency, but cleft-specific cheek soft tissue prediction data are insufficient. This 3D imaging-based study addressed the issue.

3D craniofacial soft tissue and…[Read more]

on in the development of COVID-19 vaccines.We aimed to evaluate the outcomes of patients with fulminant myocarditis and investigate the factors associated with mortality. This is a retrospective single-center cohort study that included adult and pediatric patients with fulminant myocarditis treated at Samsung Medical Center between September 2004…[Read more]

The aim of this study was to describe macular changes associated with tilted disc syndrome (TDS) using multimodality imaging.

This is a retrospective observational study of the consecutive TDS cases which were studied for macular changes using color fundus photographs and optical coherence tomography (OCT). Fundus autofluorescence, fundus…[Read more]

Western blot showed that the expression of PARP-1, PAR and AIF were decreased withPJ34 treatment. In addition, administration of PJ34 also improved the vision-dependent behavior of rat. Conclusions These findings suggested that PJ34 is a potential therapeutic agent that attenuated photoreceptor parthanatos death in retinal detachment through…[Read more]

A high-protein diet has a variety of beneficial effects and mixing isolated soybean protein (ISP) with whey protein (WP) reported to increases health and functional advantages. The objective of this study was to determine an adequate ratio for mixing these two proteins by evaluating the physical and sensory properties of protein-fortified samples.…[Read more]

This paper provides the data collected from screening chromatographic resins for their ability to bind and purify recombinant human thioredoxin from Escherichia coli lysate. This data was used by “Capture chromatography with mixed-mode resins A case study with recombinant human thioredoxin from Escherichia coli” [1] to determine the optimal resin…[Read more]

A high yield synthesis of 2-amino-4-pyrrolin-3-ones including 4-pyrrolin-3-one-based amino esters by the NBS- or TfCl-mediated reaction of 3-hydroxypyrroles with amines has been developed. The reaction of 3-hydroxypyrroles with triflyl chloride in the absence of amine affords 2,2′-bi(4-pyrrolin-3-ones) in excellent yields and diastereoselectivity.…[Read more]

Coronavirus disease 2019 (COVID-19) is a pandemic that started in China in December 2019 and carries a high risk of morbidity and mortality. To-date (4-22-2020) it affected over 2.6 million people and resulted in nearly 200,000 death worldwide mainly due to severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2). Among the major underlying…[Read more]

The complex management of severe burn victims requires an integrative collaboration of multidisciplinary specialists in order to ensure quality and excellence in healthcare. This multidisciplinary care has quickly led to the integration of cell therapies in clinical care of burn patients. Specific advances in cellular therapy together with medical…[Read more]

Background The purpose of this research was to investigate the relationship between Menopause Specific Quality of Life (MENQOL), Perceived Social Support (PSS) and factors associated with MENQOL among a group of Iranian Postmenopausal women in 2018. Methods In this cross-sectional study 410 of Postmenopausal Iranian women in Neyshabur are…[Read more]

Ventricular function in elderly patients with aortic stenosis is impeded both by restricted aortic flow and arterial stiffening. A number of patients continue to have exertional intolerance after relief of aortic valvular obstruction due to unrecognized ventriculo-arterial coupling mismatch.

Quantification of valvulo-arterial load (VAL),…[Read more]

The overall results reveal that EDTA-EMR is a promising adsorbent ascribed by its low cost, good recyclability and excellent adsorption capacity.Microplastics pollution has emerged as one of the top-ranked global environmental issues, receiving worldwide attention in recent years. However, knowledge about the detrimental effects of microplastics…[Read more]

47, p<0.001).

There is a substantial proportion of major trauma within e-scooter injuries. Modifiable risk factors for hospital admission include use of head protection and substance use while riding e-scooters.

There is a substantial proportion of major trauma within e-scooter injuries. Modifiable risk factors for hospital admission…[Read more]